Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris

K. Szabó, G. Tax, K. Kis, K. Szegedi, D. G. Teodorescu-Brinzeu, C. Diószegi, A. Koreck, M. Széll, L. Kemény

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalTissue Antigens
Volume76
Issue number5
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Interleukins
Acne Vulgaris
Causality
Alleles
Minisatellite Repeats
Homozygote
Skin Diseases
Genes
Single Nucleotide Polymorphism
Genotype

Keywords

  • +4845 (G>T)
  • Acne vulgaris
  • IL1RN
  • Interleukin-1 alpha
  • Single nucleotide polymorphism
  • VNTR

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

Szabó, K., Tax, G., Kis, K., Szegedi, K., Teodorescu-Brinzeu, D. G., Diószegi, C., ... Kemény, L. (2010). Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris. Tissue Antigens, 76(5), 411-415. https://doi.org/10.1111/j.1399-0039.2010.01530.x

Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris. / Szabó, K.; Tax, G.; Kis, K.; Szegedi, K.; Teodorescu-Brinzeu, D. G.; Diószegi, C.; Koreck, A.; Széll, M.; Kemény, L.

In: Tissue Antigens, Vol. 76, No. 5, 11.2010, p. 411-415.

Research output: Contribution to journalArticle

Szabó K, Tax G, Kis K, Szegedi K, Teodorescu-Brinzeu DG, Diószegi C et al. Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris. Tissue Antigens. 2010 Nov;76(5):411-415. https://doi.org/10.1111/j.1399-0039.2010.01530.x
Szabó, K. ; Tax, G. ; Kis, K. ; Szegedi, K. ; Teodorescu-Brinzeu, D. G. ; Diószegi, C. ; Koreck, A. ; Széll, M. ; Kemény, L. / Interleukin-1A +4845(G>T) polymorphism is a factor predisposing to acne vulgaris. In: Tissue Antigens. 2010 ; Vol. 76, No. 5. pp. 411-415.
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