Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice

Arvin Iracheta-Vellve, Jan Petrasek, Benedek Gyogyosi, Shashi Bala, Timea Csak, Karen Kodys, G. Szabó

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background & Aims: Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown. Methods: In this study, we tested IL-1 receptor antagonist to block IL-1 signalling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regeneration in AH. Results: We observed that inhibition of IL-1 signalling decreased liver inflammation and neutrophil infiltration, and resulted in enhanced regeneration of hepatocytes and increased rate of recovery from liver injury in AH. Conclusion: Our novel findings suggest that IL-1 drives sustained liver inflammation and impaired hepatocyte regeneration even after cessation of ethanol exposure.

Original languageEnglish
Pages (from-to)968-973
Number of pages6
JournalLiver International
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

Fingerprint

Alcoholic Hepatitis
Interleukin-1
Regeneration
Hepatocytes
Liver
Wounds and Injuries
Inflammation
Liver Regeneration
Interleukin-1 Receptors
Neutrophil Infiltration
Liver Failure
Ethanol
Alcohols
Cytokines

Keywords

  • alcoholic liver disease
  • interleukin 1
  • interleukin 1 receptor antagonist
  • liver regeneration

ASJC Scopus subject areas

  • Hepatology

Cite this

Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. / Iracheta-Vellve, Arvin; Petrasek, Jan; Gyogyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; Szabó, G.

In: Liver International, Vol. 37, No. 7, 01.07.2017, p. 968-973.

Research output: Contribution to journalArticle

Iracheta-Vellve, Arvin ; Petrasek, Jan ; Gyogyosi, Benedek ; Bala, Shashi ; Csak, Timea ; Kodys, Karen ; Szabó, G. / Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. In: Liver International. 2017 ; Vol. 37, No. 7. pp. 968-973.
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