Interferon production in myelo- and lymphoproliferative diseases. I. Spontaneous interferon production in acute and chronic leukaemias

B. Szabo, F. D. Toth, J. Kiss, L. Vaczi, A. Kiss, K. Rak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Blood plasma interferon (IFN) of patients with acute myeloid (AML) and chronic granulocytic (CGL) and with acute and chronic lymphoid leukaemia (ALL and CLL) was measured by bioassay and characterized by neutralization with anti-human-IFN-α treatment. Elevated IFN-α level (60-125 IU/ml) was found in the quiescent phase of CGL as compared to the control samples (15 ± 10 IU/ml). No significant differences could be found between plasma IFN of patients suffering from the blastic crisis of CGL and control persons. Analogous results were obtained in experiments with plasmas of AML patients, regardless the stage of the disease. Elevated IFN-α production (60-100 IU/ml) was found in patients being in the remission phase of T-cell ALL but only in one case in the progressive phase of the disease. No significant elevation of plasma IFN level was demonstrated in patients with O-cell ALL and B-cell CLL, as compared to the control samples.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalActa microbiologica Hungarica
Volume35
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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