Interferon production by cultured human trophoblast induced with double stranded polyribonucleotide

F. D. Toth, C. Juhl, N. Nørskov-Lauritsen, P. Mosborg Petersen, P. Ebbesen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Human trophoblast cultures were established from term placentae. Upon exposure to polyriboinosinic-polyribocytidylic acid (poly(I:C)) the cultures produced interferon. Results of neutralization experiments and indirect immunofluorescence studies indicated that the trophoblast produces beta-interferon. The fusion of trophoblast cells into syncytia was accompanied by a restriction in interferon release after stimulation with poly(I:C). It was also demonstrated that the malignant choriocarcinoma cell line JAR produced less interferon than the non-transformed cyto- or syncytiotrophoblast.

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalJournal of Reproductive Immunology
Volume17
Issue number3
DOIs
Publication statusPublished - Jun 1990

Keywords

  • human
  • interferon
  • poly(I:C)
  • tissue culture
  • trophoblast

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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