Interferon induction by different strains of infectious bronchitis virus

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Interferon (IF) inducing ability and conditions of IF production by 3 strains of infectious bronchitis virus (IBV) were compared. Only strain Beaudette at high embryo passage showed significant IF induction in chickens, in eggs and in chick embryo cell culture. Maximal yield of IF in chick cells occurred at 48 hr when about 80% of the cells showed destruction. Virus inactivation by heat or ultraviolet light, and suppression of virus growth by IF pretreatment of cells, reduced IF production. If production did not decrease significantly when the multiplicity of infection was reduced from 50 infectious units to 0.1, therefore, it has been concluded that molecules accumulating during virus replication and capable of inducing IF are more likely candidates for inducer than the RNA of the input virus. These conditions affected IF induction of Semliki Forest virus likewise, thus the IF inductions, by SFV and IBV are of similar types. Potentiating effects, such as UV irradiation of the virus and pretreatment of the cell with IF, failed to convert 2 non inducing strains of IBV into IF inducers.

Original languageEnglish
Title of host publicationACTA VET.ACAD.SCI.HUNG.
Pages199-204
Number of pages6
Volume24
Edition1-2
Publication statusPublished - 1974

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Infectious bronchitis virus
Interferons
Interferon Inducers
Semliki forest virus
Virus Inactivation
Viruses
RNA Viruses
Chick Embryo
Ultraviolet Rays
Virus Replication
Eggs
Chickens
Embryonic Structures
Cell Culture Techniques
Hot Temperature

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lomniczi, B. (1974). Interferon induction by different strains of infectious bronchitis virus. In ACTA VET.ACAD.SCI.HUNG. (1-2 ed., Vol. 24, pp. 199-204)

Interferon induction by different strains of infectious bronchitis virus. / Lomniczi, B.

ACTA VET.ACAD.SCI.HUNG.. Vol. 24 1-2. ed. 1974. p. 199-204.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lomniczi, B 1974, Interferon induction by different strains of infectious bronchitis virus. in ACTA VET.ACAD.SCI.HUNG.. 1-2 edn, vol. 24, pp. 199-204.
Lomniczi B. Interferon induction by different strains of infectious bronchitis virus. In ACTA VET.ACAD.SCI.HUNG.. 1-2 ed. Vol. 24. 1974. p. 199-204
Lomniczi, B. / Interferon induction by different strains of infectious bronchitis virus. ACTA VET.ACAD.SCI.HUNG.. Vol. 24 1-2. ed. 1974. pp. 199-204
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