Interferon induction by adenoviruses

I. Béládi, R. Pusztai, M. Bakay, I. Mucsi, B. Taródi

Research output: Contribution to journalArticle

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Abstract

All human, simian, bovine and avian adenovirus types tested so far and the canine hepatitis virus induce interferon production in chick cells. This finding indicated this property to be characteristic for viruses belonging to the adenovirus group. Trypsin treatment, which had no effect upon the infectivity, diminished or eliminated the interferon-inducing abilities of crude adenoviruses, and thus the need for a trypsin-sensitive protein in interferon induction was suggested. T antigen and interferon were formed simultaneously in chick embryo fibroblast cells infected with human adenovirus type 12, and therefore the adenovirus-specific T antigen was resistant to the action of endogenous interferon synthetized by the same cells. In chicks inoculated with human types, the appearance of interferon was biphasic: an 'early' and a 'late' interferon could be demonstrated with maximum titre 4 and 10 hr, respectively, after virus infection. In chicks infected with adenoviruses, first interferon production and then a decreased primary immune response to sheep red blood cells was observed. It was assumed that in adenovirus-infected chicks the interferon produced by viral stimulus resulted in a transient immunosuppression.

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalPostgraduate Medical Journal
Volume55
Issue number640
DOIs
Publication statusPublished - 1979

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Adenoviridae
Interferons
Human Adenoviruses
Viral Tumor Antigens
Trypsin
Simian Adenoviruses
Aviadenovirus
Canine Adenoviruses
Virus Diseases
Chick Embryo
Immunosuppression
Sheep
Fibroblasts
Erythrocytes
Viruses

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Béládi, I., Pusztai, R., Bakay, M., Mucsi, I., & Taródi, B. (1979). Interferon induction by adenoviruses. Postgraduate Medical Journal, 55(640), 128-134. https://doi.org/10.1136/pgmj.55.640.128

Interferon induction by adenoviruses. / Béládi, I.; Pusztai, R.; Bakay, M.; Mucsi, I.; Taródi, B.

In: Postgraduate Medical Journal, Vol. 55, No. 640, 1979, p. 128-134.

Research output: Contribution to journalArticle

Béládi, I, Pusztai, R, Bakay, M, Mucsi, I & Taródi, B 1979, 'Interferon induction by adenoviruses', Postgraduate Medical Journal, vol. 55, no. 640, pp. 128-134. https://doi.org/10.1136/pgmj.55.640.128
Béládi, I. ; Pusztai, R. ; Bakay, M. ; Mucsi, I. ; Taródi, B. / Interferon induction by adenoviruses. In: Postgraduate Medical Journal. 1979 ; Vol. 55, No. 640. pp. 128-134.
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