Interferon (IFN)-like antiviral effect is induced by unspecific cross-linking of cell surface receptors

György Premecz, Andrea Markovits, György Bagi, Tibor Farkas, István Földes

Research output: Contribution to journalArticle

Abstract

Treatment of human amniotic cells (UAC) with Cytodex 1 (DEAE-dextran) results in the development of an antiviral state of the cells, as proven by studying (i) the cytopathic effect and (ii) [3H]uridine incorporation into the RNA of vesicular stomatitis virus (VSV) after VSV infection. The same treatment transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C (PKC). On the basis of these data it can be suggested that cross-linking of cell surface receptors by a solid carrier bearing covalently bound positive charges may result in IFN-like effects.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalFEBS letters
Volume243
Issue number2
DOIs
Publication statusPublished - Jan 30 1989

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Keywords

  • Antiviral activity
  • Cytodex 1
  • Interferon function
  • Phosphatidylinositol turnover
  • Protein kinase C

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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