Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses

G. Gyulai, Cs B. Pénzes, M. Mohai, T. Lohner, P. Petrik, S. Kurunczi, T. E. Kiss

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Biodegradable polyesters such as poly(lactic-co-glycolic acid) copolymers (PLGA) are preferred materials for drug carrier systems although their surface hydrophobicity greatly limits their use in controlled drug delivery. PLGA thin films on a solid support blended with PEG-containing compound (Pluronic) were used as model systems to study the interfacial interactions with aqueous media. Degree of surface hydrophilization was assessed by wettability, and X-ray photoelectron spectroscopy (XPS) measurements. Protein adsorption behavior was investigated by in situ spectroscopic ellipsometry. The degree of protein adsorption showed a good correlation with the hydrophilicity, and surface composition. Unexpectedly, the layer thickness was found to have a great impact on the interfacial characteristics of the polymer films in the investigated regime (20-200. nm). Thick layers presented higher hydrophilicity and great resistance to protein adsorption. That special behavior was explained as the result of the swelling of the polymer film combined with the partial dissolution of Pluronic from the layer. This finding might promote the rational design of surface modified biocompatible nanoparticles.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalJournal of colloid and interface science
Volume362
Issue number2
DOIs
Publication statusPublished - Oct 15 2011

Keywords

  • Biocompatibility
  • Ellipsometry
  • PLGA-Pluronic blends
  • Protein adsorption
  • Surface modification
  • Wettability
  • XPS

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses'. Together they form a unique fingerprint.

  • Cite this