Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses

G. Gyulai, Cs B. Pénzes, M. Mohai, T. Lohner, P. Petrik, S. Kurunczi, E. Kiss

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Biodegradable polyesters such as poly(lactic-co-glycolic acid) copolymers (PLGA) are preferred materials for drug carrier systems although their surface hydrophobicity greatly limits their use in controlled drug delivery. PLGA thin films on a solid support blended with PEG-containing compound (Pluronic) were used as model systems to study the interfacial interactions with aqueous media. Degree of surface hydrophilization was assessed by wettability, and X-ray photoelectron spectroscopy (XPS) measurements. Protein adsorption behavior was investigated by in situ spectroscopic ellipsometry. The degree of protein adsorption showed a good correlation with the hydrophilicity, and surface composition. Unexpectedly, the layer thickness was found to have a great impact on the interfacial characteristics of the polymer films in the investigated regime (20-200. nm). Thick layers presented higher hydrophilicity and great resistance to protein adsorption. That special behavior was explained as the result of the swelling of the polymer film combined with the partial dissolution of Pluronic from the layer. This finding might promote the rational design of surface modified biocompatible nanoparticles.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalJournal of Colloid and Interface Science
Volume362
Issue number2
DOIs
Publication statusPublished - Oct 15 2011

Fingerprint

Poloxamer
Hydrophilicity
Proteins
Polymer films
Adsorption
Acids
Controlled drug delivery
Drug Carriers
Polyesters
Spectroscopic ellipsometry
Hydrophobicity
Surface structure
Polyethylene glycols
Swelling
Wetting
Dissolution
X ray photoelectron spectroscopy
Copolymers
Nanoparticles
Thin films

Keywords

  • Biocompatibility
  • Ellipsometry
  • PLGA-Pluronic blends
  • Protein adsorption
  • Surface modification
  • Wettability
  • XPS

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Colloid and Surface Chemistry

Cite this

Interfacial properties of hydrophilized poly(lactic-co-glycolic acid) layers with various thicknesses. / Gyulai, G.; Pénzes, Cs B.; Mohai, M.; Lohner, T.; Petrik, P.; Kurunczi, S.; Kiss, E.

In: Journal of Colloid and Interface Science, Vol. 362, No. 2, 15.10.2011, p. 600-606.

Research output: Contribution to journalArticle

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