Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures: A cross-sectional study

Nasim Ahmed Khan, Horace Jack Spencer, Elena Nikiphorou, Antonio Naranjo, Rieki Alten, Rodica M. Chirieac, Alexandros A. Drosos, P. Géher, Nevsun Inanc, Eduardo Kerzberg, Codrina Mihaela Ancuta, Rüediger Müller, Lykke Ornbjerg, Tuulliki Sokka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. To assess intercentre variability in the ACR core set measures, DAS28 based on three variables (DAS28v3) and Routine Assessment of Patient Index Data 3 in a multinational study. Methods. Seven thousand and twenty-three patients were recruited (84 centres; 30 countries) using a standard protocol in the Quantitative Standard Monitoring of Patients with RA study. Analysis of variance (ANOVA) and mixed-effect analysis of covariance models were used to model the relationship between study centre and different patient-reported and physician-reported RA activity measures. These models were built to adjust for the remaining ACR core set measure (for each ACR core set measure or each composite index), socio-demographics and medical characteristics. ANOVA and analysis of covariance models yielded similar results, and ANOVA tables were used to present variance attributable to recruiting centre. Results. The proportion of variances attributable to recruiting centre was lower for patient reported outcomes (PROs: pain, HAQ, patient global) compared with objective measures (joint counts, ESR, physician global) in all models. In the full model, variance in PROs attributable to recruiting centre ranged from 1.53% for patient global to 3.71% for HAQ compared with objective measures that ranged from 5.92% for physician global to 9.25% for ESR; and was lower for Routine Assessment of Patient Index Data 3 (2.6%) compared with DAS28v3 (11.75%). Conclusion. Intercentre variability in PROs is lower than objective measures of RA activity demonstrating that PROs may be more comparable across centres, and the need for standardization of objective measures.

Original languageEnglish
Pages (from-to)1395-1400
Number of pages6
JournalRheumatology (United Kingdom)
Volume56
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Rheumatoid Arthritis
Cross-Sectional Studies
ametantrone
Analysis of Variance
Physicians
Physiologic Monitoring
Patient Reported Outcome Measures
Joints
Demography
Pain

Keywords

  • Disease activity assessment
  • Intercentre variance
  • Patient reported outcomes
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures : A cross-sectional study. / Khan, Nasim Ahmed; Spencer, Horace Jack; Nikiphorou, Elena; Naranjo, Antonio; Alten, Rieki; Chirieac, Rodica M.; Drosos, Alexandros A.; Géher, P.; Inanc, Nevsun; Kerzberg, Eduardo; Ancuta, Codrina Mihaela; Müller, Rüediger; Ornbjerg, Lykke; Sokka, Tuulliki.

In: Rheumatology (United Kingdom), Vol. 56, No. 8, 01.08.2017, p. 1395-1400.

Research output: Contribution to journalArticle

Khan, NA, Spencer, HJ, Nikiphorou, E, Naranjo, A, Alten, R, Chirieac, RM, Drosos, AA, Géher, P, Inanc, N, Kerzberg, E, Ancuta, CM, Müller, R, Ornbjerg, L & Sokka, T 2017, 'Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures: A cross-sectional study', Rheumatology (United Kingdom), vol. 56, no. 8, pp. 1395-1400. https://doi.org/10.1093/rheumatology/kex076
Khan, Nasim Ahmed ; Spencer, Horace Jack ; Nikiphorou, Elena ; Naranjo, Antonio ; Alten, Rieki ; Chirieac, Rodica M. ; Drosos, Alexandros A. ; Géher, P. ; Inanc, Nevsun ; Kerzberg, Eduardo ; Ancuta, Codrina Mihaela ; Müller, Rüediger ; Ornbjerg, Lykke ; Sokka, Tuulliki. / Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures : A cross-sectional study. In: Rheumatology (United Kingdom). 2017 ; Vol. 56, No. 8. pp. 1395-1400.
@article{7cfb0fd4db8c432ea356f63179704c66,
title = "Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures: A cross-sectional study",
abstract = "Objective. To assess intercentre variability in the ACR core set measures, DAS28 based on three variables (DAS28v3) and Routine Assessment of Patient Index Data 3 in a multinational study. Methods. Seven thousand and twenty-three patients were recruited (84 centres; 30 countries) using a standard protocol in the Quantitative Standard Monitoring of Patients with RA study. Analysis of variance (ANOVA) and mixed-effect analysis of covariance models were used to model the relationship between study centre and different patient-reported and physician-reported RA activity measures. These models were built to adjust for the remaining ACR core set measure (for each ACR core set measure or each composite index), socio-demographics and medical characteristics. ANOVA and analysis of covariance models yielded similar results, and ANOVA tables were used to present variance attributable to recruiting centre. Results. The proportion of variances attributable to recruiting centre was lower for patient reported outcomes (PROs: pain, HAQ, patient global) compared with objective measures (joint counts, ESR, physician global) in all models. In the full model, variance in PROs attributable to recruiting centre ranged from 1.53{\%} for patient global to 3.71{\%} for HAQ compared with objective measures that ranged from 5.92{\%} for physician global to 9.25{\%} for ESR; and was lower for Routine Assessment of Patient Index Data 3 (2.6{\%}) compared with DAS28v3 (11.75{\%}). Conclusion. Intercentre variability in PROs is lower than objective measures of RA activity demonstrating that PROs may be more comparable across centres, and the need for standardization of objective measures.",
keywords = "Disease activity assessment, Intercentre variance, Patient reported outcomes, Rheumatoid arthritis",
author = "Khan, {Nasim Ahmed} and Spencer, {Horace Jack} and Elena Nikiphorou and Antonio Naranjo and Rieki Alten and Chirieac, {Rodica M.} and Drosos, {Alexandros A.} and P. G{\'e}her and Nevsun Inanc and Eduardo Kerzberg and Ancuta, {Codrina Mihaela} and R{\"u}ediger M{\"u}ller and Lykke Ornbjerg and Tuulliki Sokka",
year = "2017",
month = "8",
day = "1",
doi = "10.1093/rheumatology/kex076",
language = "English",
volume = "56",
pages = "1395--1400",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - Intercentre variance in patient reported outcomes is lower than objective rheumatoid arthritis activity measures

T2 - A cross-sectional study

AU - Khan, Nasim Ahmed

AU - Spencer, Horace Jack

AU - Nikiphorou, Elena

AU - Naranjo, Antonio

AU - Alten, Rieki

AU - Chirieac, Rodica M.

AU - Drosos, Alexandros A.

AU - Géher, P.

AU - Inanc, Nevsun

AU - Kerzberg, Eduardo

AU - Ancuta, Codrina Mihaela

AU - Müller, Rüediger

AU - Ornbjerg, Lykke

AU - Sokka, Tuulliki

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objective. To assess intercentre variability in the ACR core set measures, DAS28 based on three variables (DAS28v3) and Routine Assessment of Patient Index Data 3 in a multinational study. Methods. Seven thousand and twenty-three patients were recruited (84 centres; 30 countries) using a standard protocol in the Quantitative Standard Monitoring of Patients with RA study. Analysis of variance (ANOVA) and mixed-effect analysis of covariance models were used to model the relationship between study centre and different patient-reported and physician-reported RA activity measures. These models were built to adjust for the remaining ACR core set measure (for each ACR core set measure or each composite index), socio-demographics and medical characteristics. ANOVA and analysis of covariance models yielded similar results, and ANOVA tables were used to present variance attributable to recruiting centre. Results. The proportion of variances attributable to recruiting centre was lower for patient reported outcomes (PROs: pain, HAQ, patient global) compared with objective measures (joint counts, ESR, physician global) in all models. In the full model, variance in PROs attributable to recruiting centre ranged from 1.53% for patient global to 3.71% for HAQ compared with objective measures that ranged from 5.92% for physician global to 9.25% for ESR; and was lower for Routine Assessment of Patient Index Data 3 (2.6%) compared with DAS28v3 (11.75%). Conclusion. Intercentre variability in PROs is lower than objective measures of RA activity demonstrating that PROs may be more comparable across centres, and the need for standardization of objective measures.

AB - Objective. To assess intercentre variability in the ACR core set measures, DAS28 based on three variables (DAS28v3) and Routine Assessment of Patient Index Data 3 in a multinational study. Methods. Seven thousand and twenty-three patients were recruited (84 centres; 30 countries) using a standard protocol in the Quantitative Standard Monitoring of Patients with RA study. Analysis of variance (ANOVA) and mixed-effect analysis of covariance models were used to model the relationship between study centre and different patient-reported and physician-reported RA activity measures. These models were built to adjust for the remaining ACR core set measure (for each ACR core set measure or each composite index), socio-demographics and medical characteristics. ANOVA and analysis of covariance models yielded similar results, and ANOVA tables were used to present variance attributable to recruiting centre. Results. The proportion of variances attributable to recruiting centre was lower for patient reported outcomes (PROs: pain, HAQ, patient global) compared with objective measures (joint counts, ESR, physician global) in all models. In the full model, variance in PROs attributable to recruiting centre ranged from 1.53% for patient global to 3.71% for HAQ compared with objective measures that ranged from 5.92% for physician global to 9.25% for ESR; and was lower for Routine Assessment of Patient Index Data 3 (2.6%) compared with DAS28v3 (11.75%). Conclusion. Intercentre variability in PROs is lower than objective measures of RA activity demonstrating that PROs may be more comparable across centres, and the need for standardization of objective measures.

KW - Disease activity assessment

KW - Intercentre variance

KW - Patient reported outcomes

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=85028346045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028346045&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/kex076

DO - 10.1093/rheumatology/kex076

M3 - Article

C2 - 28575509

AN - SCOPUS:85028346045

VL - 56

SP - 1395

EP - 1400

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 8

ER -