Interbirth interval is associated with childhood type 1 diabetes risk

Chris R. Cardwell, Jannet Svensson, Thomas Waldhoer, Johnny Ludvigsson, Vaiva Sadauskaite-Kuehne, Christine L. Roberts, Roger C. Parslow, Emma J K Wadsworth, Girts Brigis, Brone Urbonaite, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. De Beaufort, G. Soltész, Chris C. Patterson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalDiabetes
Volume61
Issue number3
DOIs
Publication statusPublished - Mar 2012

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Type 1 Diabetes Mellitus
Mothers
Risk Reduction Behavior
Odds Ratio
Micronutrients
Autistic Disorder
Observational Studies
Siblings
Leukemia
Infection

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Cardwell, C. R., Svensson, J., Waldhoer, T., Ludvigsson, J., Sadauskaite-Kuehne, V., Roberts, C. L., ... Patterson, C. C. (2012). Interbirth interval is associated with childhood type 1 diabetes risk. Diabetes, 61(3), 702-707. https://doi.org/10.2337/db11-1000

Interbirth interval is associated with childhood type 1 diabetes risk. / Cardwell, Chris R.; Svensson, Jannet; Waldhoer, Thomas; Ludvigsson, Johnny; Sadauskaite-Kuehne, Vaiva; Roberts, Christine L.; Parslow, Roger C.; Wadsworth, Emma J K; Brigis, Girts; Urbonaite, Brone; Schober, Edith; Devoti, Gabriele; Ionescu-Tirgoviste, Constantin; De Beaufort, Carine E.; Soltész, G.; Patterson, Chris C.

In: Diabetes, Vol. 61, No. 3, 03.2012, p. 702-707.

Research output: Contribution to journalArticle

Cardwell, CR, Svensson, J, Waldhoer, T, Ludvigsson, J, Sadauskaite-Kuehne, V, Roberts, CL, Parslow, RC, Wadsworth, EJK, Brigis, G, Urbonaite, B, Schober, E, Devoti, G, Ionescu-Tirgoviste, C, De Beaufort, CE, Soltész, G & Patterson, CC 2012, 'Interbirth interval is associated with childhood type 1 diabetes risk', Diabetes, vol. 61, no. 3, pp. 702-707. https://doi.org/10.2337/db11-1000
Cardwell CR, Svensson J, Waldhoer T, Ludvigsson J, Sadauskaite-Kuehne V, Roberts CL et al. Interbirth interval is associated with childhood type 1 diabetes risk. Diabetes. 2012 Mar;61(3):702-707. https://doi.org/10.2337/db11-1000
Cardwell, Chris R. ; Svensson, Jannet ; Waldhoer, Thomas ; Ludvigsson, Johnny ; Sadauskaite-Kuehne, Vaiva ; Roberts, Christine L. ; Parslow, Roger C. ; Wadsworth, Emma J K ; Brigis, Girts ; Urbonaite, Brone ; Schober, Edith ; Devoti, Gabriele ; Ionescu-Tirgoviste, Constantin ; De Beaufort, Carine E. ; Soltész, G. ; Patterson, Chris C. / Interbirth interval is associated with childhood type 1 diabetes risk. In: Diabetes. 2012 ; Vol. 61, No. 3. pp. 702-707.
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