Interacttion of some anti-hypoxia drugs with hydroxypropyl-β-cyclodextrin studied by means of charge transfer chromatography

Sylvie Wallerstein, Tibor Cserháti

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Abstract

The interaction of 12 anti-hypoxia drugs with hydroxypropyl-β-cyclodextrin (HPBCD) and the influence of LiCi, NaCl and KCl on the strength of interaction was studied by charge transfer chromatography. Most of the drugs form inclusion complexes with HPBCD and the relative strengh of interaction varies markedly according to the structure of the drugs. Salts exert a considerable influence on the inclusion complex formation and the effect depends on hthe radaii of the cation. The significant correlations between the lipophilicity of drugs and their capacity to form inclusion complexes with HPBCD indicate the involvement of hydrophobic forces in the interaction.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalJournal of biochemical and biophysical methods
Volume29
Issue number1
DOIs
Publication statusPublished - Jul 1994

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Keywords

  • Anti-hypoxia drug
  • Charge transfer chromatography
  • Hydroxypropyl-β-cyclodextrin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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