Interactions of zearalenone with native and chemically modified cyclodextrins and their potential utilization

Miklós Poór, Sándor Kunsági-Máté, Nikolett Sali, Tamás Koszegi, Lajos Szente, Beáta Peles-Lemli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Abstract Zearalenone (ZEA) is a widespread xenoestrogenic mycotoxin produced by several Fusarium species. ZEA can cause reproductive disorders in farm animals and hyperoestrogenic syndromes in humans; therefore, development of more sensitive analytical methods (to quantify the mycotoxin) as well as strategies for prevention of its toxic impacts is highly important. In this study, the interactions of ZEA with native and chemically modified cyclodextrins (CDs) were investigated using fluorescence spectroscopy. Furthermore, in vitro experiments on liver cells were also performed to test the potential effect of CDs on toxin uptake. Our results demonstrate that ZEA forms stable complexes with CDs (log K values are approximately 3.7-4.7) resulting in the considerable elevation of its fluorescence signal. In addition, some of the CDs show ability to inhibit the cellular uptake of ZEA, suggesting their potential suitability to develop new CD-based preventive/detoxification strategies against ZEA in the future.

Original languageEnglish
Article number10084
Pages (from-to)63-68
Number of pages6
JournalJournal of Photochemistry and Photobiology B: Biology
Volume151
DOIs
Publication statusPublished - Jul 15 2015

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Keywords

  • Cyclodextrin
  • Detoxification
  • Fluorescence enhancement
  • Fluorescence spectroscopy
  • Zearalenone

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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