Interactions of oxovanadium(IV) and the quinolone family member - Ciprofloxacin

Iztok Turel, Amalija Golobič, Aleš Klavžar, Boris Pihlar, P. Buglyó, Evangelos Tolis, Dieter Rehder, Kristina Sepčić

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The interactions of quinolone ciprofloxacin (cfH) and oxovanadium(IV) were studied by various methods. Green crystals of a complex [VIVO(cf)2(H2O)] were isolated and the molecular connectivities established, although the crystal structure was not perfectly refined due to the instability of the crystals. Based on a plausible interpretation of the data sets, two cf anions bidentately coordinate to a vanadyl cation through carboxylate and carbonyl oxygen atoms; in addition, there is a water molecule in the coordination sphere. Solution techniques (cyclic voltammetry, electronic and electron paramagnetic resonance spectroscopy, potentiometric measurements) confirmed the presence of various species in the solution, the composition of which strongly depends on the conditions in the system. The antibacterial activity of the complex against various microorganisms was tested and it was established that its activity is similar to that of free ciprofloxacin.

Original languageEnglish
Pages (from-to)199-207
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume95
Issue number2-3
DOIs
Publication statusPublished - Jun 1 2003

Fingerprint

Quinolones
Ciprofloxacin
Crystals
Vanadates
Electron Spin Resonance Spectroscopy
Microorganisms
Cyclic voltammetry
Anions
Paramagnetic resonance
Cations
Spectrum Analysis
Crystal structure
Spectroscopy
Oxygen
Atoms
Molecules
Water
Chemical analysis
oxovanadium IV
Datasets

Keywords

  • Antibacterial activity
  • Ciprofloxacin
  • Oxovanadium(IV)
  • Solution equilibria
  • X-ray structure

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Interactions of oxovanadium(IV) and the quinolone family member - Ciprofloxacin. / Turel, Iztok; Golobič, Amalija; Klavžar, Aleš; Pihlar, Boris; Buglyó, P.; Tolis, Evangelos; Rehder, Dieter; Sepčić, Kristina.

In: Journal of Inorganic Biochemistry, Vol. 95, No. 2-3, 01.06.2003, p. 199-207.

Research output: Contribution to journalArticle

Turel, I, Golobič, A, Klavžar, A, Pihlar, B, Buglyó, P, Tolis, E, Rehder, D & Sepčić, K 2003, 'Interactions of oxovanadium(IV) and the quinolone family member - Ciprofloxacin', Journal of Inorganic Biochemistry, vol. 95, no. 2-3, pp. 199-207. https://doi.org/10.1016/S0162-0134(03)00123-5
Turel, Iztok ; Golobič, Amalija ; Klavžar, Aleš ; Pihlar, Boris ; Buglyó, P. ; Tolis, Evangelos ; Rehder, Dieter ; Sepčić, Kristina. / Interactions of oxovanadium(IV) and the quinolone family member - Ciprofloxacin. In: Journal of Inorganic Biochemistry. 2003 ; Vol. 95, No. 2-3. pp. 199-207.
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