Interactions of Aluminum(III) with Phosphates

Károly Atkári, T. Kiss, Roberta Bertani, R. Bruce Martin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In order to obtain information about aluminum(III)-phosphate interactions, potentiometric measurements were carried out to characterize the complex forming properties of Al(III) with organic phosphates, phosphonates, and nucleoside-5′-monophosphates. The aluminum(III)-orthophosphate system is difficult to study due to AlPO4 precipitation. To overcome this problem, the stability constant logarithms of the 1:1 Al(III) complexes of ligands with the same donor groups (log K1:1) were plotted against the basicities of the ligands (log KPO3H). The resulting linear free energy relation (LFER) indicates that organic phosphates, phosphonates, and uridine-, thymidine-, and guanosine 5′-monophosphates similarly bind Al(III). Adenosine and cytidine 5′-monophosphate fall above the LFER owing to the presence of a second microform with the nucleic base protonated and a hydroxide bound to the Al(III). From the LFER the log stability constant for Al(III) binding to HPO42- is estimated as 6.13 ± 0.05. From the weakness of any soluble orthophosphate complexes of Al(III) we confirm the importance of citrate as the main small molecule Al3+ binder in the blood serum. The study includes investigation of Al(III) binding to di- and triphosphates, which bind metal ion differently than monophosphates. Structures of the complexes were supported by 31P NMR measurements.

Original languageEnglish
Pages (from-to)7089-7094
Number of pages6
JournalInorganic Chemistry
Volume35
Issue number24
Publication statusPublished - 1996

Fingerprint

Aluminum
Free energy
Organophosphonates
phosphates
Organophosphates
free energy
Phosphates
aluminum
Microforms
blood serum
Ligands
Guanosine Monophosphate
guanosines
diphosphates
Cytidine
thymidine
adenosines
ligands
nucleosides
Diphosphates

ASJC Scopus subject areas

  • Inorganic Chemistry

Cite this

Atkári, K., Kiss, T., Bertani, R., & Bruce Martin, R. (1996). Interactions of Aluminum(III) with Phosphates. Inorganic Chemistry, 35(24), 7089-7094.

Interactions of Aluminum(III) with Phosphates. / Atkári, Károly; Kiss, T.; Bertani, Roberta; Bruce Martin, R.

In: Inorganic Chemistry, Vol. 35, No. 24, 1996, p. 7089-7094.

Research output: Contribution to journalArticle

Atkári, K, Kiss, T, Bertani, R & Bruce Martin, R 1996, 'Interactions of Aluminum(III) with Phosphates', Inorganic Chemistry, vol. 35, no. 24, pp. 7089-7094.
Atkári K, Kiss T, Bertani R, Bruce Martin R. Interactions of Aluminum(III) with Phosphates. Inorganic Chemistry. 1996;35(24):7089-7094.
Atkári, Károly ; Kiss, T. ; Bertani, Roberta ; Bruce Martin, R. / Interactions of Aluminum(III) with Phosphates. In: Inorganic Chemistry. 1996 ; Vol. 35, No. 24. pp. 7089-7094.
@article{eaa76bdbdd6248f4b9bef429f336457d,
title = "Interactions of Aluminum(III) with Phosphates",
abstract = "In order to obtain information about aluminum(III)-phosphate interactions, potentiometric measurements were carried out to characterize the complex forming properties of Al(III) with organic phosphates, phosphonates, and nucleoside-5′-monophosphates. The aluminum(III)-orthophosphate system is difficult to study due to AlPO4 precipitation. To overcome this problem, the stability constant logarithms of the 1:1 Al(III) complexes of ligands with the same donor groups (log K1:1) were plotted against the basicities of the ligands (log KPO3H). The resulting linear free energy relation (LFER) indicates that organic phosphates, phosphonates, and uridine-, thymidine-, and guanosine 5′-monophosphates similarly bind Al(III). Adenosine and cytidine 5′-monophosphate fall above the LFER owing to the presence of a second microform with the nucleic base protonated and a hydroxide bound to the Al(III). From the LFER the log stability constant for Al(III) binding to HPO42- is estimated as 6.13 ± 0.05. From the weakness of any soluble orthophosphate complexes of Al(III) we confirm the importance of citrate as the main small molecule Al3+ binder in the blood serum. The study includes investigation of Al(III) binding to di- and triphosphates, which bind metal ion differently than monophosphates. Structures of the complexes were supported by 31P NMR measurements.",
author = "K{\'a}roly Atk{\'a}ri and T. Kiss and Roberta Bertani and {Bruce Martin}, R.",
year = "1996",
language = "English",
volume = "35",
pages = "7089--7094",
journal = "Inorganic Chemistry",
issn = "0020-1669",
publisher = "American Chemical Society",
number = "24",

}

TY - JOUR

T1 - Interactions of Aluminum(III) with Phosphates

AU - Atkári, Károly

AU - Kiss, T.

AU - Bertani, Roberta

AU - Bruce Martin, R.

PY - 1996

Y1 - 1996

N2 - In order to obtain information about aluminum(III)-phosphate interactions, potentiometric measurements were carried out to characterize the complex forming properties of Al(III) with organic phosphates, phosphonates, and nucleoside-5′-monophosphates. The aluminum(III)-orthophosphate system is difficult to study due to AlPO4 precipitation. To overcome this problem, the stability constant logarithms of the 1:1 Al(III) complexes of ligands with the same donor groups (log K1:1) were plotted against the basicities of the ligands (log KPO3H). The resulting linear free energy relation (LFER) indicates that organic phosphates, phosphonates, and uridine-, thymidine-, and guanosine 5′-monophosphates similarly bind Al(III). Adenosine and cytidine 5′-monophosphate fall above the LFER owing to the presence of a second microform with the nucleic base protonated and a hydroxide bound to the Al(III). From the LFER the log stability constant for Al(III) binding to HPO42- is estimated as 6.13 ± 0.05. From the weakness of any soluble orthophosphate complexes of Al(III) we confirm the importance of citrate as the main small molecule Al3+ binder in the blood serum. The study includes investigation of Al(III) binding to di- and triphosphates, which bind metal ion differently than monophosphates. Structures of the complexes were supported by 31P NMR measurements.

AB - In order to obtain information about aluminum(III)-phosphate interactions, potentiometric measurements were carried out to characterize the complex forming properties of Al(III) with organic phosphates, phosphonates, and nucleoside-5′-monophosphates. The aluminum(III)-orthophosphate system is difficult to study due to AlPO4 precipitation. To overcome this problem, the stability constant logarithms of the 1:1 Al(III) complexes of ligands with the same donor groups (log K1:1) were plotted against the basicities of the ligands (log KPO3H). The resulting linear free energy relation (LFER) indicates that organic phosphates, phosphonates, and uridine-, thymidine-, and guanosine 5′-monophosphates similarly bind Al(III). Adenosine and cytidine 5′-monophosphate fall above the LFER owing to the presence of a second microform with the nucleic base protonated and a hydroxide bound to the Al(III). From the LFER the log stability constant for Al(III) binding to HPO42- is estimated as 6.13 ± 0.05. From the weakness of any soluble orthophosphate complexes of Al(III) we confirm the importance of citrate as the main small molecule Al3+ binder in the blood serum. The study includes investigation of Al(III) binding to di- and triphosphates, which bind metal ion differently than monophosphates. Structures of the complexes were supported by 31P NMR measurements.

UR - http://www.scopus.com/inward/record.url?scp=0038366797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038366797&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 7089

EP - 7094

JO - Inorganic Chemistry

JF - Inorganic Chemistry

SN - 0020-1669

IS - 24

ER -