Interactions of Al(III) with a neurofilament heptapeptide fragment: AcLysSerProValValGluGly

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Abstract

The solution state of the neurotoxic Al(III) in biological systems is discussed briefly, and the importance of the Al(III)-peptide and Al(III)-protein interactions in the various neurodegeneration processes is emphasised and evaluated. The possible involvement of Al(III) in the formation of Alzheimer's disease marker senile plaques and neurofilament tangles is discussed in light of the solution speciation of the Al(III)-AcLysSerProValValGluGly system and the structural features of the complexes formed.

Original languageEnglish
Pages (from-to)227-236
Number of pages10
JournalCoordination Chemistry Reviews
Volume228
Issue number2
DOIs
Publication statusPublished - Jun 3 2002

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fragments
Biological systems
markers
Peptides
peptides
interactions
proteins
Proteins

Keywords

  • Al(III)-complexes
  • Molecular dynamics calculations
  • NMR
  • Speciation

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

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title = "Interactions of Al(III) with a neurofilament heptapeptide fragment: AcLysSerProValValGluGly",
abstract = "The solution state of the neurotoxic Al(III) in biological systems is discussed briefly, and the importance of the Al(III)-peptide and Al(III)-protein interactions in the various neurodegeneration processes is emphasised and evaluated. The possible involvement of Al(III) in the formation of Alzheimer's disease marker senile plaques and neurofilament tangles is discussed in light of the solution speciation of the Al(III)-AcLysSerProValValGluGly system and the structural features of the complexes formed.",
keywords = "Al(III)-complexes, Molecular dynamics calculations, NMR, Speciation",
author = "T. Kiss and M. Kily{\'e}n and A. Lakatos and F. Evanics and T. K{\"o}rtv{\'e}lyesi and G. Dombi and Zs. Majer and M. Holl{\'o}si",
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T1 - Interactions of Al(III) with a neurofilament heptapeptide fragment

T2 - AcLysSerProValValGluGly

AU - Kiss, T.

AU - Kilyén, M.

AU - Lakatos, A.

AU - Evanics, F.

AU - Körtvélyesi, T.

AU - Dombi, G.

AU - Majer, Zs.

AU - Hollósi, M.

PY - 2002/6/3

Y1 - 2002/6/3

N2 - The solution state of the neurotoxic Al(III) in biological systems is discussed briefly, and the importance of the Al(III)-peptide and Al(III)-protein interactions in the various neurodegeneration processes is emphasised and evaluated. The possible involvement of Al(III) in the formation of Alzheimer's disease marker senile plaques and neurofilament tangles is discussed in light of the solution speciation of the Al(III)-AcLysSerProValValGluGly system and the structural features of the complexes formed.

AB - The solution state of the neurotoxic Al(III) in biological systems is discussed briefly, and the importance of the Al(III)-peptide and Al(III)-protein interactions in the various neurodegeneration processes is emphasised and evaluated. The possible involvement of Al(III) in the formation of Alzheimer's disease marker senile plaques and neurofilament tangles is discussed in light of the solution speciation of the Al(III)-AcLysSerProValValGluGly system and the structural features of the complexes formed.

KW - Al(III)-complexes

KW - Molecular dynamics calculations

KW - NMR

KW - Speciation

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