Ciklodextrinek és sztatinok kölcsönhatásának in vitro vizsgálatai

Translated title of the contribution: Interactions in solution between cyclodextrins and statins

András Süle, Lajos Szente, F. Csempesz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cyclodextrins (CDs) are cyclic oligosaccharides, capable of forming inclusion complexes with hydrophobic molecules in aqueous solution and therefore, of improving the bioavailability of many drugs. They are biocompatible with living cells and do not cause toxic side effects. In this study, interactions in aqueous solutions between chemically different CDs and lovastatin and simvastatin, respectively, were investigated. It was found that the solubility of both statins can be considerably increased by the CD derivatives. The influence of the chemical structure of CD and of the temperature and pH on the solubility of the statin derivatives is described. Possible ways of increasing the solubility of these cholesterol-lowering drugs and their utilization in practice are also outlined.

Original languageHungarian
Pages (from-to)179-183
Number of pages5
JournalActa Pharmaceutica Hungarica
Volume75
Issue number4
Publication statusPublished - 2005

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cyclodextrins
Solubility
Drug Utilization
Lovastatin
Simvastatin
Poisons
Oligosaccharides
Biological Availability
Cholesterol
Temperature
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Ciklodextrinek és sztatinok kölcsönhatásának in vitro vizsgálatai. / Süle, András; Szente, Lajos; Csempesz, F.

In: Acta Pharmaceutica Hungarica, Vol. 75, No. 4, 2005, p. 179-183.

Research output: Contribution to journalArticle

Süle, András ; Szente, Lajos ; Csempesz, F. / Ciklodextrinek és sztatinok kölcsönhatásának in vitro vizsgálatai. In: Acta Pharmaceutica Hungarica. 2005 ; Vol. 75, No. 4. pp. 179-183.
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