Interactions between LPS moieties and macrophage pattern recognition receptors

Zsuzsanna Gyorfy, Erno Duda, Csaba Vizler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Mammalian host organisms live their life constantly interacting with pathogenic and non-pathogenic Gram-negative bacteria. Commensal/symbiont strains are tolerated in the gut, while pathogens are kept at bay by the immune system. In contrast both commensals and pathogenic bacteria are targets of the immune system outside of the digestive system. Immune cells are activated upon contact with different constituents of bacterial cells like peptidoglycan, outer membrane proteins, fimbriae, bacterial DNA, etc. One of the dominant molecular targets affecting the immune cells is the lipopolysaccharide (LPS), an essential molecule of the cell wall of Gram-negative bacteria. In this review we discuss interactions of macrophages with the main LPS moieties lipid A, core and O-antigen regions.

Original languageEnglish
Pages (from-to)28-36
Number of pages9
JournalVeterinary Immunology and Immunopathology
Volume152
Issue number1-2
DOIs
Publication statusPublished - Mar 15 2013

Fingerprint

Pattern Recognition Receptors
lipopolysaccharides
Lipopolysaccharides
macrophages
Macrophages
Gram-Negative Bacteria
Gram-negative bacteria
receptors
immune system
Immune System
digestive system
Digestive System
O Antigens
Bacterial DNA
Lipid A
Peptidoglycan
outer membrane proteins
fimbriae
peptidoglycans
cells

Keywords

  • Gram-negative bacterium
  • Innate immunity
  • Lipid A
  • Lipopolysaccharide
  • Macrophage

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Interactions between LPS moieties and macrophage pattern recognition receptors. / Gyorfy, Zsuzsanna; Duda, Erno; Vizler, Csaba.

In: Veterinary Immunology and Immunopathology, Vol. 152, No. 1-2, 15.03.2013, p. 28-36.

Research output: Contribution to journalArticle

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