Interactions between cyclodextrins and cell-membrane phospholipids

J. Szejtli, T. Cserháti, M. Szögyi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The interactions between cyclodextrins (CDs) and selected cell membrane phospholipids, liposomes and human erythrocytes were studied. Non-methylated cyclodextrins did not influence the differential scanning calorimetric behaviour of phospholipids and did not increase the permeability of dipalmitoyl-phosphatidyl-choline liposomes. Dimethyl- and trimethyl- β-CD interacted with the phospholipids but the effect was negligible compared to the effect of valinomycin. Reversed-phase thin-layer chromatography revealed complex formation with dimethyl-β-cyclodextrin, but not with others. The addition of cyclodextrins up to 10-2 mol litre-1 concentration did not modify the active or passive alkali ion transport of human erythrocytes, however, higher concentrations of added β-cyclodextrin especially dimethyl-β-cyclodextrin resulted in hemolysis.

Original languageEnglish
Pages (from-to)35-49
Number of pages15
JournalCarbohydrate Polymers
Volume6
Issue number1
DOIs
Publication statusPublished - 1986

Fingerprint

cyclodextrins
Phospholipids
Cyclodextrins
Cell membranes
cell membranes
phospholipids
Cell Membrane
Liposomes
erythrocytes
Erythrocytes
valinomycin
Valinomycin
Thin layer chromatography
Ion Transport
hemolysis
Alkalies
ion transport
Reverse-Phase Chromatography
choline
Thin Layer Chromatography

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

Interactions between cyclodextrins and cell-membrane phospholipids. / Szejtli, J.; Cserháti, T.; Szögyi, M.

In: Carbohydrate Polymers, Vol. 6, No. 1, 1986, p. 35-49.

Research output: Contribution to journalArticle

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