Interaction of taxol and other anticancer drugs with hydroxypropyl-β-cyclodextrin

T. Cserháti, János Holló

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The interaction between 23 anticancer drugs and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. HPβCD formed inclusion complexes with 15 compounds, the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably according to their chemical structure. The intensity of interaction significantly increased with increasing hydrophobicity of the guest molecule, demonstrating the preponderant role of hydrophobic interactions in inclusion complex formation.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume108
Issue number1
DOIs
Publication statusPublished - Jul 25 1994

Fingerprint

Cyclodextrins
Paclitaxel
Hydrophobic and Hydrophilic Interactions
Pharmaceutical Preparations
Thin Layer Chromatography

Keywords

  • Anticancer drug
  • Hydrophobic interaction
  • Hydroxypropyl-β-cyclodextrin

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Interaction of taxol and other anticancer drugs with hydroxypropyl-β-cyclodextrin. / Cserháti, T.; Holló, János.

In: International Journal of Pharmaceutics, Vol. 108, No. 1, 25.07.1994, p. 69-75.

Research output: Contribution to journalArticle

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