Interaction of taxol and other anticancer drugs with α-cyclodextrin

T. Cserháti, E. Forgács, János Holló

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The interaction between 23 anticancer drugs and α-cyclodextrin (α-CD) was studied by reversed-phase charge-transrer thin-layer chromatography and the relative strength of interaction was calculated. As α-CD has smaller cavity than β- and τ-CD it interacted only with 10 anticancer drugs proving the relatively poor complex forming capacity of α-CD. The hydrophobicity of host-guest inclusion complex was always different from that of the uncomplexed drug suggesting that the complex formation may influence the uptake, absorption, half-life etc. of the original drug. the inclusion forming capacity of drugs differed considerably according to their chemical structure. The intensity of interaction significantly depended on the hydrophobicity of the guest molecule proving the preponderant role of hydrophobic interactions in inclusion complex formation.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume13
Issue number4-5
DOIs
Publication statusPublished - 1995

Fingerprint

Cyclodextrins
Paclitaxel
Hydrophobic and Hydrophilic Interactions
Pharmaceutical Preparations
Hydrophobicity
Thin layer chromatography
Thin Layer Chromatography
Half-Life
Molecules

Keywords

  • anticancer drugs
  • charge-transfer chromatography
  • α-cyclodextrin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Interaction of taxol and other anticancer drugs with α-cyclodextrin. / Cserháti, T.; Forgács, E.; Holló, János.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 13, No. 4-5, 1995, p. 533-541.

Research output: Contribution to journalArticle

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