Interaction of substance P and opiates in the CNS of Helix pomatia L.

Jànos salánki, Agnes Vehovszky, George B. Stefano

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Abstract

1. The present report demonstrates that substance P excites the RPal neuron. There is a delay in the onset of the substance-P-induced excitation: however, once achieved it is prolonged. 2. Morphine depresses the bursting activity of this neuron, an activity which can be blocked by naloxone. 3. Morphine, in a naloxone-reversible manner, can partially alter the excitatory effect of substance P on the RPal neuron. 4. The response of the RPal neuron to substance P depends on the physiological state of the organism. 5. The study demonstrates that substance P and opiates are acting on the same unit by different mechanisms. It also suggests the existence of a separate substance P receptor.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume75
Issue number2
DOIs
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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