Interaction of some barbituric acid derivatives with hydroxypropyl-β-cyclodextrin

Katalin Csabai, T. Cserháti, József Szejtli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The interaction between 39 barbituric acid derivatives and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by reversed-phase charge-transfer thin-layer chromatography. Except for one derivative, each barbiturate formed inclusion complexes with HPβCD, the complex always being more hydrophilic than the uncomplexed drug. The intensity of interaction significantly increased with increasing lipophilicity of the guest molecule proving the preponderant role of hydrophobic interactions in inclusion complex formation. The di- and trisubstituted derivatives probably formed complexes of different stoichiometry. Free-Wilson analysis proved that the intensity of interaction increases with increasing size of the substituents at least in the studied range.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume91
Issue number1
DOIs
Publication statusPublished - Apr 5 1993

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Cyclodextrins
Thin Layer Chromatography
Hydrophobic and Hydrophilic Interactions
Pharmaceutical Preparations
barbituric acid

Keywords

  • Barbiturate
  • Hydroxypropyl-β-cyclodextrin
  • Inclusion complex

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Interaction of some barbituric acid derivatives with hydroxypropyl-β-cyclodextrin. / Csabai, Katalin; Cserháti, T.; Szejtli, József.

In: International Journal of Pharmaceutics, Vol. 91, No. 1, 05.04.1993, p. 15-22.

Research output: Contribution to journalArticle

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