Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Tímea Gombos, Zsolt Förhécz, Zoltán Pozsonyi, Lívia Jánoskuti, Z. Prohászka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised in clinical samples. Aims: The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels. Methods: A total of 167 patients (123 men, 44 women) with

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalCell Stress and Chaperones
Volume13
Issue number2
DOIs
Publication statusPublished - Jun 2008

Fingerprint

HSP70 Heat-Shock Proteins
Polymorphism
Heart Failure
Genes
Serum
Blood Proteins
Alleles
Population

Keywords

  • Heart failure
  • Inflammation
  • Liver
  • Stress proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure. / Gombos, Tímea; Förhécz, Zsolt; Pozsonyi, Zoltán; Jánoskuti, Lívia; Prohászka, Z.

In: Cell Stress and Chaperones, Vol. 13, No. 2, 06.2008, p. 199-206.

Research output: Contribution to journalArticle

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