Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces

Gergő Gyulai, E. Kiss

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hypothesis Adsorption and localization of nanoparticles at fluid interfaces are key factors in processes like transport through membranes or emulsion stabilization. Adsorption of poly(lactic-co-glycolic acid) (PLGA) and Pluronic coated PLGA nanoparticles (NPs) were studied at three different fluid interfaces. The effect of particle surface modification and type of interface was investigated with the aim of fine tuning interfacial interaction of the nanoparticles. Experiments Surface tension measurements were carried out to determine the surface activity and adsorption kinetics of the particles. Particles layers at the air/water interface were further studied using the Langmuir balance technique by recording the surface pressure–area isotherms. Interfacial rheological measurements were performed to characterize the structural properties of the nanoparticle interfacial films. Findings Interfacial adsorption and its kinetics were explained by the diffusion controlled adsorption theory and considering the energy barrier of particle transport to the interface. Surface modification by Pluronic increased the interfacial activity of nanoparticles at all interfaces. Surface activity of PLGA-Pluronic particles could be described by the contributions of both the PLGA NPs and the effective portion of their Pluronic shell. Both particle films present mainly elastic dilatational properties suggesting that particles are in kinetically separated state.

Original languageEnglish
Pages (from-to)9-19
Number of pages11
JournalJournal of Colloid and Interface Science
Volume500
DOIs
Publication statusPublished - Aug 15 2017

Fingerprint

Poloxamer
Nanoparticles
Fluids
Acids
Adsorption
Surface treatment
Kinetics
Energy barriers
Emulsions
Isotherms
Surface tension
polylactic acid-polyglycolic acid copolymer
Milk
Structural properties
Stabilization
Tuning
Membranes
Water
Air
Experiments

Keywords

  • Adsorption kinetics
  • Interfacial dilatational rheology
  • Interfacial structure
  • PLGA nanoparticles
  • Pluronic stabilized nanoparticles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces. / Gyulai, Gergő; Kiss, E.

In: Journal of Colloid and Interface Science, Vol. 500, 15.08.2017, p. 9-19.

Research output: Contribution to journalArticle

@article{50ffa885ae8f4759a969bbbfa0ab838e,
title = "Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces",
abstract = "Hypothesis Adsorption and localization of nanoparticles at fluid interfaces are key factors in processes like transport through membranes or emulsion stabilization. Adsorption of poly(lactic-co-glycolic acid) (PLGA) and Pluronic coated PLGA nanoparticles (NPs) were studied at three different fluid interfaces. The effect of particle surface modification and type of interface was investigated with the aim of fine tuning interfacial interaction of the nanoparticles. Experiments Surface tension measurements were carried out to determine the surface activity and adsorption kinetics of the particles. Particles layers at the air/water interface were further studied using the Langmuir balance technique by recording the surface pressure–area isotherms. Interfacial rheological measurements were performed to characterize the structural properties of the nanoparticle interfacial films. Findings Interfacial adsorption and its kinetics were explained by the diffusion controlled adsorption theory and considering the energy barrier of particle transport to the interface. Surface modification by Pluronic increased the interfacial activity of nanoparticles at all interfaces. Surface activity of PLGA-Pluronic particles could be described by the contributions of both the PLGA NPs and the effective portion of their Pluronic shell. Both particle films present mainly elastic dilatational properties suggesting that particles are in kinetically separated state.",
keywords = "Adsorption kinetics, Interfacial dilatational rheology, Interfacial structure, PLGA nanoparticles, Pluronic stabilized nanoparticles",
author = "Gergő Gyulai and E. Kiss",
year = "2017",
month = "8",
day = "15",
doi = "10.1016/j.jcis.2017.03.114",
language = "English",
volume = "500",
pages = "9--19",
journal = "Journal of Colloid and Interface Science",
issn = "0021-9797",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Interaction of poly(lactic-co-glycolic acid) nanoparticles at fluid interfaces

AU - Gyulai, Gergő

AU - Kiss, E.

PY - 2017/8/15

Y1 - 2017/8/15

N2 - Hypothesis Adsorption and localization of nanoparticles at fluid interfaces are key factors in processes like transport through membranes or emulsion stabilization. Adsorption of poly(lactic-co-glycolic acid) (PLGA) and Pluronic coated PLGA nanoparticles (NPs) were studied at three different fluid interfaces. The effect of particle surface modification and type of interface was investigated with the aim of fine tuning interfacial interaction of the nanoparticles. Experiments Surface tension measurements were carried out to determine the surface activity and adsorption kinetics of the particles. Particles layers at the air/water interface were further studied using the Langmuir balance technique by recording the surface pressure–area isotherms. Interfacial rheological measurements were performed to characterize the structural properties of the nanoparticle interfacial films. Findings Interfacial adsorption and its kinetics were explained by the diffusion controlled adsorption theory and considering the energy barrier of particle transport to the interface. Surface modification by Pluronic increased the interfacial activity of nanoparticles at all interfaces. Surface activity of PLGA-Pluronic particles could be described by the contributions of both the PLGA NPs and the effective portion of their Pluronic shell. Both particle films present mainly elastic dilatational properties suggesting that particles are in kinetically separated state.

AB - Hypothesis Adsorption and localization of nanoparticles at fluid interfaces are key factors in processes like transport through membranes or emulsion stabilization. Adsorption of poly(lactic-co-glycolic acid) (PLGA) and Pluronic coated PLGA nanoparticles (NPs) were studied at three different fluid interfaces. The effect of particle surface modification and type of interface was investigated with the aim of fine tuning interfacial interaction of the nanoparticles. Experiments Surface tension measurements were carried out to determine the surface activity and adsorption kinetics of the particles. Particles layers at the air/water interface were further studied using the Langmuir balance technique by recording the surface pressure–area isotherms. Interfacial rheological measurements were performed to characterize the structural properties of the nanoparticle interfacial films. Findings Interfacial adsorption and its kinetics were explained by the diffusion controlled adsorption theory and considering the energy barrier of particle transport to the interface. Surface modification by Pluronic increased the interfacial activity of nanoparticles at all interfaces. Surface activity of PLGA-Pluronic particles could be described by the contributions of both the PLGA NPs and the effective portion of their Pluronic shell. Both particle films present mainly elastic dilatational properties suggesting that particles are in kinetically separated state.

KW - Adsorption kinetics

KW - Interfacial dilatational rheology

KW - Interfacial structure

KW - PLGA nanoparticles

KW - Pluronic stabilized nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=85017158038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017158038&partnerID=8YFLogxK

U2 - 10.1016/j.jcis.2017.03.114

DO - 10.1016/j.jcis.2017.03.114

M3 - Article

AN - SCOPUS:85017158038

VL - 500

SP - 9

EP - 19

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

SN - 0021-9797

ER -