Interaction of ochratoxin A with quaternary ammonium beta-cyclodextrin

Miklós Poór, Sándor Kunsági-Máté, Lajos Szente, Gergely Matisz, Györgyi Secenji, Zsuzsanna Czibulya, Tamás Koszegi

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17 Citations (Scopus)

Abstract

Ochratoxin A (OTA) is a widely spread nephrotoxic food contaminant mycotoxin. Unfortunately, attenuation or prevention of the toxic effects of OTA is still an unresolved problem. Molecular inclusion of OTA by cyclodextrins (CDs) results in complexes with low stability. In the human organism, OTA exists mostly in the dianionic state (OTA2-). Therefore, our major goal was to develop a chemically modified cyclodextrin which gives a more stable complex with OTA than the previously published derivatives and which shows stronger preference towards OTA2-. In our fluorescence spectroscopic study we demonstrate that quaternary ammonium beta-cyclodextrin (QABCD) fulfils both of these requirements. The calculated stability constant of the QABCD-OTA2- complex was 28,840 M-1 (about 200-fold higher than that of the β-CD-OTA2- complex). We hypothesize, that QABCD may be a suitable tool for the decontamination of different OTA-contaminated drinks; furthermore, for alleviation of the toxic effects of OTA, such complex formation may reduce its absorption from the intestine.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalFood Chemistry
Volume172
DOIs
Publication statusPublished - Apr 1 2015

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Keywords

  • Cyclodextrin
  • Detoxification
  • Fluorescence spectroscopy
  • Molecular inclusion
  • Ochratoxin A

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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