Interaction of monovalent cationic drugs with montmorillonite

Ildikó Fejér, Mihály Kata, I. Erös, I. Dékány

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The aim of this study was to compare the adsorption of various organic drugs and a well-studied surfactant. The organic drugs used were promethazine chloride [10-(2-dimethylammonium) propylfenothiazine chloride] and buformin hydrochloride (1-butylbiguanidine chloride). The surfactant was benzalkonium chloride (N-tridecyl-N-benzyl-N,N-dimethylammonium chloride). Different amounts of drug solutions were added to montmorillonite suspensions, either separately (simple system) or in combination (competitive system) under the same conditions, and the organocomplexes formed were investigated. The organic molecule with the short alkyl chain adsorbed to yield monolayer coverage, whereas the aromatic molecule and the surfactant formed a pseudotrimolecular arrangement. In the competitive system, the larger organic molecules (having the same charge) displaced the smaller one from the interlayer space. The intercalation of molecules in the interlayer space was investigated by X-ray diffraction measurements.

Original languageEnglish
Pages (from-to)372-379
Number of pages8
JournalColloid & Polymer Science
Volume280
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Bentonite
montmorillonite
Clay minerals
drugs
chlorides
Surface-Active Agents
Molecules
Surface active agents
Pharmaceutical Preparations
surfactants
Chlorides
Buformin
interactions
molecules
Benzalkonium Compounds
interlayers
Promethazine
promethazine
Intercalation
hydrochlorides

Keywords

  • Clay-mineral organocomplexes
  • Competitive adsorption
  • Drug intercalation
  • Montmorillonite
  • X-ray diffraction measurements

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Interaction of monovalent cationic drugs with montmorillonite. / Fejér, Ildikó; Kata, Mihály; Erös, I.; Dékány, I.

In: Colloid & Polymer Science, Vol. 280, No. 4, 2002, p. 372-379.

Research output: Contribution to journalArticle

Fejér, Ildikó ; Kata, Mihály ; Erös, I. ; Dékány, I. / Interaction of monovalent cationic drugs with montmorillonite. In: Colloid & Polymer Science. 2002 ; Vol. 280, No. 4. pp. 372-379.
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