Interaction of monoamine oxidase inhibitors with glutamic acid, and the effect of salt on the strength of the interaction

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Abstract

The interaction of seventeen monoamine oxidase inhibitory drugs (propargylamine derivatives) with glutamic acid, and the effect of salt on the strength of the interaction has been studied by charge-transfer chromatography performed on reversed-phase TLC plates. The data set was evaluated by stepwise regression analysis and principal components analysis. Each drug interacted with glutamic acid, the strength of the interaction depending on the type of substituent on the propargylamine. Sodium chloride significantly reduced the strength of the interaction, suggesting the involvement of hydrophilic forces in the binding of glutamic acid to drugs. This finding makes probable the direct binding of drugs to the secondary carboxyl group of glutamic acids in the target enzyme or enzymes.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Planar Chromatography - Modern TLC
Volume8
Issue number2
Publication statusPublished - Jan 1 1995

Keywords

  • glutamic acid
  • hydrophilic interaction
  • monoamine oxidase inhibitors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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