Interaction of hydro- or lipophilic phthalocyanines with cells of different metastatic potential

Giuliana Valduga, Gianluca Bianco, Gabriella Csik, Elana Reddi, Laura Masiero, Spiridione Garbisa, Giulio Jori

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15 Citations (Scopus)


A highly metastatic (4R) and a nonmetastatic (RE4) transformed rat embryo fibroblast cell line were incubated with lipid-soluble Zn(II)-phthalocyanine (ZnPc) and its water-soluble tetrasulphonated derivative (ZnPcTS) and compared for phthalocyanine uptake. The hydrophobic liposome-delivered ZnPc showed a significantly greater uptake by both cell lines than did ZnPcTS. Moreover, the two phthalocyanines appear to interact with cells according to different pathways, as suggested by the different temperature-dependence of the binding process and the different inhibitory action exerted by selected serum proteins, such as lipoproteins and heavy proteins. Under all experimental conditions, the two cell lines exhibited similar interactions with ZnPc and ZnPcTS, suggesting that heterogeneity of the tumor cell population has a minor influence on the accumulation of photosensitizers.

Original languageEnglish
Pages (from-to)585-590
Number of pages6
JournalBiochemical Pharmacology
Issue number5
Publication statusPublished - Mar 8 1996


  • metastatic potential
  • phthalocyanine
  • serum proteins

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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