Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

H. Chinoy, S. Adimulam, F. Marriage, P. New, M. Vincze, E. Zilahi, A. Kapitány, A. Gyetvai, L. Ekholm, P. Novota, M. Remakova, P. Charles, N. J. McHugh, L. Padyukov, L. Alfredsson, J. Vencovsky, I. E. Lundberg, K. Dankó, W. E. Ollier, Robert G. Cooper

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Abstract

Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

Original languageEnglish
Pages (from-to)961-965
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number6
DOIs
Publication statusPublished - Jun 2012

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HLA-DRB1 Chains
Myositis
Smoking
Histidine-tRNA Ligase
Oligonucleotides
Assays
Tissue
Hungary
Czech Republic
DNA
Immunoprecipitation
Sweden
Jo-1 antibody
History
Lung

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies : A European-wide case study. / Chinoy, H.; Adimulam, S.; Marriage, F.; New, P.; Vincze, M.; Zilahi, E.; Kapitány, A.; Gyetvai, A.; Ekholm, L.; Novota, P.; Remakova, M.; Charles, P.; McHugh, N. J.; Padyukov, L.; Alfredsson, L.; Vencovsky, J.; Lundberg, I. E.; Dankó, K.; Ollier, W. E.; Cooper, Robert G.

In: Annals of the Rheumatic Diseases, Vol. 71, No. 6, 06.2012, p. 961-965.

Research output: Contribution to journalArticle

Chinoy, H, Adimulam, S, Marriage, F, New, P, Vincze, M, Zilahi, E, Kapitány, A, Gyetvai, A, Ekholm, L, Novota, P, Remakova, M, Charles, P, McHugh, NJ, Padyukov, L, Alfredsson, L, Vencovsky, J, Lundberg, IE, Dankó, K, Ollier, WE & Cooper, RG 2012, 'Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study', Annals of the Rheumatic Diseases, vol. 71, no. 6, pp. 961-965. https://doi.org/10.1136/annrheumdis-2011-200182
Chinoy, H. ; Adimulam, S. ; Marriage, F. ; New, P. ; Vincze, M. ; Zilahi, E. ; Kapitány, A. ; Gyetvai, A. ; Ekholm, L. ; Novota, P. ; Remakova, M. ; Charles, P. ; McHugh, N. J. ; Padyukov, L. ; Alfredsson, L. ; Vencovsky, J. ; Lundberg, I. E. ; Dankó, K. ; Ollier, W. E. ; Cooper, Robert G. / Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies : A European-wide case study. In: Annals of the Rheumatic Diseases. 2012 ; Vol. 71, No. 6. pp. 961-965.
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abstract = "Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45{\%} Jo-1-positive vs 17{\%} Jo-1-negative, OR 3.94, 95{\%} CI 1.53 to 9.89, p",
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AU - Chinoy, H.

AU - Adimulam, S.

AU - Marriage, F.

AU - New, P.

AU - Vincze, M.

AU - Zilahi, E.

AU - Kapitány, A.

AU - Gyetvai, A.

AU - Ekholm, L.

AU - Novota, P.

AU - Remakova, M.

AU - Charles, P.

AU - McHugh, N. J.

AU - Padyukov, L.

AU - Alfredsson, L.

AU - Vencovsky, J.

AU - Lundberg, I. E.

AU - Dankó, K.

AU - Ollier, W. E.

AU - Cooper, Robert G.

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N2 - Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

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