Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system

Makoto Demura, Tsutomu Yoshida, Takatsugu Hirokawa, Yasuhiro Kumaki, Tomoyasu Aizawa, Katsutoshi Nitta, Isván Bitter, Klára Tóth

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The molecular recognition of neurotransmitters, dopamine and acetylcholine with an amphiphilic resorcinarene receptor was investigated in an aqueous sodium dodecylsulfate (SDS) micelle system by 1H NMR measurements. The interaction distances of these neurotransmitters from the hydrophilic cavity of the amphiphilic receptor were estimated based on the calculation of the ring current shift using the atomic coordinates obtained from molecular dynamics calculation.

Original languageEnglish
Pages (from-to)1367-1370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number5
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • Acetylcholine
  • NMR
  • Receptor
  • Resorcinarene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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