Interaction of carboxymethyl‐γ‐cyclodextrin with anticancer drugs studied by charge‐transfer thin‐layer chromatography

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6 Citations (Scopus)

Abstract

The interaction between 22 anticancer drugs and carboxymethyl‐γ‐cyclodextrin (CM‐γ‐CD) was studied by reversed‐phase charge‐transfer thin‐layer chromatography and the relative strenth of interaction was calculated. CM‐γCD formed inclusion complexes with 11 compounds, the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably according to their chemical structure. Both principal component analysis and cluster analysis found a relationship between the inclusion complex forming capacity and hydrophobicity parameters of anticancer drugs. This result suggests that the preponderant role of hydrophobic interactions is in inclusion complex formation.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalBiomedical Chromatography
Volume8
Issue number6
DOIs
Publication statusPublished - Jan 1 1994

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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