Interaction of antiviral nucleosides with gamma cyclodextrin studied by charge-transfer thin-layer chromatography

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Abstract

The interaction of twelve 8-substituted-2'-deoxyadenosine and seventeen 5-substituted-2'-deoxyuridine derivatives with gamma-cyclodextrin (GCD) was studied by charge-transfer chromatography carried out on reversed-phase layers and the relative strength of interaction was calculated. GCD formed inclusion complexes with the majority of drugs modifying in this manner the lipophilicity of the uncomplexed molecule. The capacity of Antiviral nucleosides to form inclusion complexes differed considerably depending on their chemical structures.

Original languageEnglish
Pages (from-to)125-135
Number of pages11
JournalJournal of Liquid Chromatography and Related Technologies
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry

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