Interaction of aluminium(III) with phosphate-binding sites: Biological aspects and implications

T. Kiss, P. Zatta, B. Corain

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The occurrence of abnormal levels of Al(III) connected with human pathologies and with encephalopathies experimentally induced in experimental animals is reviewed and critically evaluated in molecular terms. It is assumed that phosphate-bearing biomolecules are elected targets for the biochemical action of Al(III) and the reactivity of the metal centre towards both inorganic phosphates and nucleotides, diphosphoglycerate, phosphorylated proteins, phospholipids and myo-inositol-phosphates is thoroughly reviewed. All these data are evaluated in the light of the potential relevance of higher Al(III) levels to the etiopathology of dialysis dementia and of Alzheimer's disease.

Original languageEnglish
Pages (from-to)329-346
Number of pages18
JournalCoordination Chemistry Reviews
Volume149
Publication statusPublished - Mar 1996

Fingerprint

Binding sites
Aluminum
phosphates
Phosphates
Bearings (structural)
Binding Sites
aluminum
Inositol Phosphates
Dialysis
human pathology
Biomolecules
Pathology
inositols
dialysis
Phospholipids
Animals
Nucleotides
Metals
nucleotides
interactions

Keywords

  • Al(III)-biophosphate complexes
  • Solution speciation, Al(III) toxicity

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Interaction of aluminium(III) with phosphate-binding sites : Biological aspects and implications. / Kiss, T.; Zatta, P.; Corain, B.

In: Coordination Chemistry Reviews, Vol. 149, 03.1996, p. 329-346.

Research output: Contribution to journalArticle

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