Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[a]phenothiazine

Ilona Mucsi, Andreas Varga, Masami Kawase, Noboru Motohashi, Joseph Molnar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effect of some resistance modifiers on apoptosis induction by a benzo[a]phenothiazine derivative was studied on the L5178Y mouse lymphoma cells (parent) and its multidrug resistant (MDR) subline. For evaluation of apoptosis the cells were stained with FITC-labelled annexin V and propidium iodide and the results were analysed by flow cytometry. 12H-benzo[a]phenothiazine [M627] induced apoptosis both in the parent cells and in the MDR cells. The apoptosis induction by [M627] was not affected significantly by post- or pre-treatment with resistance modifiers, while in the cells treated by (±)-verapamil before and after apoptosis induction with [M627], the apoptosis was somewhat higher. The resistance modifier compounds alone also induced apoptosis and it was slightly higher in the parent cells than its MDR1/A gene-transformed subline.

Original languageEnglish
Pages (from-to)2833-2836
Number of pages4
JournalAnticancer research
Volume22
Issue number5
Publication statusPublished - Sep 1 2002

Keywords

  • 12H-benzo[α]phenothiazine
  • Apoptosis induction
  • Mouse T cell lymphoma cells
  • Resistance modifiers
  • Trifluoroketones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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