Interaction between tricyclic psychopharmacons and some antibiotics.

J. Molnár, N. Bathó, V. Csík, J. Chevalier, A. Cremieux

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The tricyclic psychopharmacons, e.g. clozapine, promethazine and imipramine cure plasmids and inhibit plasmid transfer among bacteria due to the inhibition of supercoiling activity on DNA gyrase. In addition an interaction was found between clozapine, imipramine, promethazine and some antibiotics, e.g. penicillins and tetracycline in vitro. The nature of interaction is based on a charge transfer complex, which is formed between clozapine, imipramine, promethazine and penicillins. Differential spectrophotometry showed that ampicillin reduced the highest energy peaks of clozapine, promethazine and imipramine. Streptomycin did not alter the spectrum of clozapine; however, tetracycline somewhat reduced all the peaks of clozapine. Clozapine and promethazine exhibited a synergistic effect with ampicillin, tetracycline and gentamicin on Escherichia coli cells in in vitro. This kind of interaction was missing in the case of imipramine.

Original languageEnglish
Pages (from-to)277-285
Number of pages9
JournalActa Microbiologica et Immunologica Hungarica
Volume42
Issue number3
Publication statusPublished - 1995

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Clozapine
Promethazine
Imipramine
Anti-Bacterial Agents
Tetracycline
Ampicillin
Penicillins
Plasmids
DNA Gyrase
Spectrophotometry
Streptomycin
Gentamicins
Escherichia coli
Bacteria

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

Interaction between tricyclic psychopharmacons and some antibiotics. / Molnár, J.; Bathó, N.; Csík, V.; Chevalier, J.; Cremieux, A.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 42, No. 3, 1995, p. 277-285.

Research output: Contribution to journalArticle

Molnár, J, Bathó, N, Csík, V, Chevalier, J & Cremieux, A 1995, 'Interaction between tricyclic psychopharmacons and some antibiotics.', Acta Microbiologica et Immunologica Hungarica, vol. 42, no. 3, pp. 277-285.
Molnár, J. ; Bathó, N. ; Csík, V. ; Chevalier, J. ; Cremieux, A. / Interaction between tricyclic psychopharmacons and some antibiotics. In: Acta Microbiologica et Immunologica Hungarica. 1995 ; Vol. 42, No. 3. pp. 277-285.
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