Abstract
The tricyclic psychopharmacons, e.g. clozapine, promethazine and imipramine cure plasmids and inhibit plasmid transfer among bacteria due to the inhibition of supercoiling activity on DNA gyrase. In addition an interaction was found between clozapine, imipramine, promethazine and some antibiotics, e.g. penicillins and tetracycline in vitro. The nature of interaction is based on a charge transfer complex, which is formed between clozapine, imipramine, promethazine and penicillins. Differential spectrophotometry showed that ampicillin reduced the highest energy peaks of clozapine, promethazine and imipramine. Streptomycin did not alter the spectrum of clozapine; however, tetracycline somewhat reduced all the peaks of clozapine. Clozapine and promethazine exhibited a synergistic effect with ampicillin, tetracycline and gentamicin on Escherichia coli cells in in vitro. This kind of interaction was missing in the case of imipramine.
| Original language | English |
|---|---|
| Pages (from-to) | 277-285 |
| Number of pages | 9 |
| Journal | Acta Microbiologica et Immunologica Hungarica |
| Volume | 42 |
| Issue number | 3 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Medicine(all)
- Microbiology
Cite this
Interaction between tricyclic psychopharmacons and some antibiotics. / Molnár, J.; Bathó, N.; Csík, V.; Chevalier, J.; Cremieux, A.
In: Acta Microbiologica et Immunologica Hungarica, Vol. 42, No. 3, 1995, p. 277-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction between tricyclic psychopharmacons and some antibiotics.
AU - Molnár, J.
AU - Bathó, N.
AU - Csík, V.
AU - Chevalier, J.
AU - Cremieux, A.
PY - 1995
Y1 - 1995
N2 - The tricyclic psychopharmacons, e.g. clozapine, promethazine and imipramine cure plasmids and inhibit plasmid transfer among bacteria due to the inhibition of supercoiling activity on DNA gyrase. In addition an interaction was found between clozapine, imipramine, promethazine and some antibiotics, e.g. penicillins and tetracycline in vitro. The nature of interaction is based on a charge transfer complex, which is formed between clozapine, imipramine, promethazine and penicillins. Differential spectrophotometry showed that ampicillin reduced the highest energy peaks of clozapine, promethazine and imipramine. Streptomycin did not alter the spectrum of clozapine; however, tetracycline somewhat reduced all the peaks of clozapine. Clozapine and promethazine exhibited a synergistic effect with ampicillin, tetracycline and gentamicin on Escherichia coli cells in in vitro. This kind of interaction was missing in the case of imipramine.
AB - The tricyclic psychopharmacons, e.g. clozapine, promethazine and imipramine cure plasmids and inhibit plasmid transfer among bacteria due to the inhibition of supercoiling activity on DNA gyrase. In addition an interaction was found between clozapine, imipramine, promethazine and some antibiotics, e.g. penicillins and tetracycline in vitro. The nature of interaction is based on a charge transfer complex, which is formed between clozapine, imipramine, promethazine and penicillins. Differential spectrophotometry showed that ampicillin reduced the highest energy peaks of clozapine, promethazine and imipramine. Streptomycin did not alter the spectrum of clozapine; however, tetracycline somewhat reduced all the peaks of clozapine. Clozapine and promethazine exhibited a synergistic effect with ampicillin, tetracycline and gentamicin on Escherichia coli cells in in vitro. This kind of interaction was missing in the case of imipramine.
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M3 - Article
C2 - 8548201
AN - SCOPUS:0029450055
VL - 42
SP - 277
EP - 285
JO - Acta Microbiologica et Immunologica Hungarica
JF - Acta Microbiologica et Immunologica Hungarica
SN - 1217-8950
IS - 3
ER -