Interaction between the three frequently co-occurring Fusarium mycotoxins in rats

Judit Szabó-Fodor, András Szabó, Dániel Kócsó, Kinga Marosi, Brigitta Bóta, Mariam Kachlek, M. Mézes, K. Balogh, György Kövér, István Nagy, Róbert Glávits, Melinda Kovács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To test the complex, acute biochemical effects of combined, naturally co-occurring fusariotoxins, a 5-day rat study was performed. Mycotoxin treatment was invented by intraperitoneal injection: FB1 (F): 9 µg/animal/day (approx. 30 µg/kg bw/day), DON (D): 16.5 µg/animal/day (approx. 55 µg/kg bw/day) and ZEN (Z): 12.75 µg/animal/day (approx. 42.5 µg/kg bw/day). The binary groups (FB1 and DON [FD], FB1 and ZEN [FZ] and DON and ZEN [DZ]) as well as the ternary (FB1, DON and ZEN [FDZ]) group were dosed at the same combined level as the individual mycotoxins. Body weight, feed intake and mortality were not affected by any of the treatments. FB1 and DON in combination (FD) increased the plasma aspartate aminotransferase activity synergistically (compared to the individual FB1 and DON). In the liver, both the total glutathione (GSH) and the glutathione peroxidase (GPx) activity were increased (p < 0.05) by the binary FB1 and ZEN (FZ) and the DON and ZEN (DZ) groups as well as the ternary FB1, DON and ZEA group (FDZ) compared to the control. The GSH level of the ternary group was significantly increased compared to the FB1 group, whereas the GPx activity of the ternary group was significantly increased compared to all three the individual mycotoxin groups. The Bliss independence method revealed synergism between DON and ZEN (DZ), as well as FB1 and DON (FD) on liver GPx activity. None of the toxins alone or in combination exerted strong genotoxicity on lymphocytes, neither on the gross histopathological characteristics. However, even at these low levels acute exposure of more than one of these mycotoxins (FB1, DON and ZEN) affected metabolic and detoxification changes.

Original languageEnglish
JournalJournal of Animal Physiology and Animal Nutrition
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Mycotoxins
Fusarium
mycotoxins
Glutathione Peroxidase
glutathione peroxidase
rats
T-2 Toxin
animals
liver
acute exposure
Liver
genotoxicity
synergism
intraperitoneal injection
Aspartate Aminotransferases
Intraperitoneal Injections
aspartate transaminase
Glutathione
glutathione
toxins

Keywords

  • deoxynivalenol
  • fumonisin
  • interaction
  • rat
  • zearalenone

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

Cite this

Szabó-Fodor, J., Szabó, A., Kócsó, D., Marosi, K., Bóta, B., Kachlek, M., ... Kovács, M. (Accepted/In press). Interaction between the three frequently co-occurring Fusarium mycotoxins in rats. Journal of Animal Physiology and Animal Nutrition. https://doi.org/10.1111/jpn.13013

Interaction between the three frequently co-occurring Fusarium mycotoxins in rats. / Szabó-Fodor, Judit; Szabó, András; Kócsó, Dániel; Marosi, Kinga; Bóta, Brigitta; Kachlek, Mariam; Mézes, M.; Balogh, K.; Kövér, György; Nagy, István; Glávits, Róbert; Kovács, Melinda.

In: Journal of Animal Physiology and Animal Nutrition, 01.01.2018.

Research output: Contribution to journalArticle

Szabó-Fodor, J, Szabó, A, Kócsó, D, Marosi, K, Bóta, B, Kachlek, M, Mézes, M, Balogh, K, Kövér, G, Nagy, I, Glávits, R & Kovács, M 2018, 'Interaction between the three frequently co-occurring Fusarium mycotoxins in rats', Journal of Animal Physiology and Animal Nutrition. https://doi.org/10.1111/jpn.13013
Szabó-Fodor, Judit ; Szabó, András ; Kócsó, Dániel ; Marosi, Kinga ; Bóta, Brigitta ; Kachlek, Mariam ; Mézes, M. ; Balogh, K. ; Kövér, György ; Nagy, István ; Glávits, Róbert ; Kovács, Melinda. / Interaction between the three frequently co-occurring Fusarium mycotoxins in rats. In: Journal of Animal Physiology and Animal Nutrition. 2018.
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