Interaction between iron(II) and hydroxamic acids: Oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions

E. Farkas, E. Enyedy, László Zékány, G. Deák

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61 Citations (Scopus)

Abstract

Interaction between iron(II) and acetohydroxamic acid (Aha), α-alaninehydroxamic acid (α-Alaha), β-alaninehydroxamic acid (β-Alaha), hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha) or desferrioxamine B (DFB) under anaerobic conditions was studied by pH-metric and UV-Visible spectrophotometric methods. The stability constants of complexes formed with Aha, α-Alaha, β-Alaha and Dha were calculated and turned out to be much lower than those of the corresponding iron(III) complexes. Stability constants of the iron(II)-hydroxamate complexes are compared with those of other divalent 3d-block metal ions and the Irving-Williams series of stabilities was found to be observed. Above pH 4, in the reactions between iron(II) and desferrioxamine B, the oxidation of the metal ion to iron(III) by the ligand was found. The overall reaction that resulted in the formation of the tris-hydroxamato complex [Fe(HDFB)]+ and monoamide derivative of DFB at pH 6 is:2Fe2++3H4DFB+=2[Fe(HDFB)]++H3DFB-monoamide++H2O+4H+Based on these results, the conclusion is that desferrioxamine B can uptake iron in iron(III) form under anaerobic conditions.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume83
Issue number2-3
DOIs
Publication statusPublished - Jan 15 2001

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Hydroxamic Acids
Deferoxamine
Iron
Oxidation
Metal ions
Metals
Ions
Acids
Amides
Ligands

Keywords

  • Anaerobic oxidation
  • Complex
  • Desferrioxamine B
  • Fe(II)/Fe(III)
  • Hydroxamic acid

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

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title = "Interaction between iron(II) and hydroxamic acids: Oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions",
abstract = "Interaction between iron(II) and acetohydroxamic acid (Aha), α-alaninehydroxamic acid (α-Alaha), β-alaninehydroxamic acid (β-Alaha), hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha) or desferrioxamine B (DFB) under anaerobic conditions was studied by pH-metric and UV-Visible spectrophotometric methods. The stability constants of complexes formed with Aha, α-Alaha, β-Alaha and Dha were calculated and turned out to be much lower than those of the corresponding iron(III) complexes. Stability constants of the iron(II)-hydroxamate complexes are compared with those of other divalent 3d-block metal ions and the Irving-Williams series of stabilities was found to be observed. Above pH 4, in the reactions between iron(II) and desferrioxamine B, the oxidation of the metal ion to iron(III) by the ligand was found. The overall reaction that resulted in the formation of the tris-hydroxamato complex [Fe(HDFB)]+ and monoamide derivative of DFB at pH 6 is:2Fe2++3H4DFB+=2[Fe(HDFB)]++H3DFB-monoamide++H2O+4H+Based on these results, the conclusion is that desferrioxamine B can uptake iron in iron(III) form under anaerobic conditions.",
keywords = "Anaerobic oxidation, Complex, Desferrioxamine B, Fe(II)/Fe(III), Hydroxamic acid",
author = "E. Farkas and E. Enyedy and L{\'a}szl{\'o} Z{\'e}k{\'a}ny and G. De{\'a}k",
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TY - JOUR

T1 - Interaction between iron(II) and hydroxamic acids

T2 - Oxidation of iron(II) to iron(III) by desferrioxamine B under anaerobic conditions

AU - Farkas, E.

AU - Enyedy, E.

AU - Zékány, László

AU - Deák, G.

PY - 2001/1/15

Y1 - 2001/1/15

N2 - Interaction between iron(II) and acetohydroxamic acid (Aha), α-alaninehydroxamic acid (α-Alaha), β-alaninehydroxamic acid (β-Alaha), hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha) or desferrioxamine B (DFB) under anaerobic conditions was studied by pH-metric and UV-Visible spectrophotometric methods. The stability constants of complexes formed with Aha, α-Alaha, β-Alaha and Dha were calculated and turned out to be much lower than those of the corresponding iron(III) complexes. Stability constants of the iron(II)-hydroxamate complexes are compared with those of other divalent 3d-block metal ions and the Irving-Williams series of stabilities was found to be observed. Above pH 4, in the reactions between iron(II) and desferrioxamine B, the oxidation of the metal ion to iron(III) by the ligand was found. The overall reaction that resulted in the formation of the tris-hydroxamato complex [Fe(HDFB)]+ and monoamide derivative of DFB at pH 6 is:2Fe2++3H4DFB+=2[Fe(HDFB)]++H3DFB-monoamide++H2O+4H+Based on these results, the conclusion is that desferrioxamine B can uptake iron in iron(III) form under anaerobic conditions.

AB - Interaction between iron(II) and acetohydroxamic acid (Aha), α-alaninehydroxamic acid (α-Alaha), β-alaninehydroxamic acid (β-Alaha), hexanedioic acid bis(3-hydroxycarbamoyl-methyl)amide (Dha) or desferrioxamine B (DFB) under anaerobic conditions was studied by pH-metric and UV-Visible spectrophotometric methods. The stability constants of complexes formed with Aha, α-Alaha, β-Alaha and Dha were calculated and turned out to be much lower than those of the corresponding iron(III) complexes. Stability constants of the iron(II)-hydroxamate complexes are compared with those of other divalent 3d-block metal ions and the Irving-Williams series of stabilities was found to be observed. Above pH 4, in the reactions between iron(II) and desferrioxamine B, the oxidation of the metal ion to iron(III) by the ligand was found. The overall reaction that resulted in the formation of the tris-hydroxamato complex [Fe(HDFB)]+ and monoamide derivative of DFB at pH 6 is:2Fe2++3H4DFB+=2[Fe(HDFB)]++H3DFB-monoamide++H2O+4H+Based on these results, the conclusion is that desferrioxamine B can uptake iron in iron(III) form under anaerobic conditions.

KW - Anaerobic oxidation

KW - Complex

KW - Desferrioxamine B

KW - Fe(II)/Fe(III)

KW - Hydroxamic acid

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