Interaction between antibiotics and non-conventional antibiotics on bacteria

Gyöngyi Gunics, Noboru Motohashi, Leonard Amaral, Sandor Farkas, J. Molnár

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The individual activity of antibiotics such as ampicillin, tetracycline, erythromycin and gentamicin in combination with compounds known to modify bacterial resistance to given antibiotics was studied using the checkerboard method. The combination of promethazine with either ampicillin, tetracycline or erythromycin or the combination of methylene blue and erythromycin produced significant synergistic activity against Escherichia coli. Verapamil, however, in combination with ampicillin reduced the activity of ampicillin against E. coli. Combinations of clomipramine with either tetracycline or erythromycin, promethazine and erythromycin or verapamil and ampicillin were synergistic against Staphylococcus epidermidis that was resistant to these antibiotics. The only synergy against Pseudomonas aeruginosa was shown by the combination of methylene blue and gentamicin. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 2000

Fingerprint

Erythromycin
Ampicillin
Anti-Bacterial Agents
Bacteria
Tetracycline
Promethazine
Methylene Blue
Verapamil
Gentamicins
Escherichia coli
Clomipramine
Staphylococcus epidermidis
Pseudomonas aeruginosa

Keywords

  • Antibiotics
  • Resistance modifiers
  • Synergism

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Interaction between antibiotics and non-conventional antibiotics on bacteria. / Gunics, Gyöngyi; Motohashi, Noboru; Amaral, Leonard; Farkas, Sandor; Molnár, J.

In: International Journal of Antimicrobial Agents, Vol. 14, No. 3, 04.2000, p. 239-242.

Research output: Contribution to journalArticle

Gunics, Gyöngyi ; Motohashi, Noboru ; Amaral, Leonard ; Farkas, Sandor ; Molnár, J. / Interaction between antibiotics and non-conventional antibiotics on bacteria. In: International Journal of Antimicrobial Agents. 2000 ; Vol. 14, No. 3. pp. 239-242.
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