Aim: The effect of p53 Arg72Pro, and X-ray cross complementing 1 Arg399Gln allelic polymorphisms on the risk of colorectal cancer was studied in a case control study. The results were combined with the data from a previous study (polymorphisms of metabolizing enzymes), and a combined analysis for the joint effect of 7 allelic polymorphisms was also performed. Materials and methods: Five hundred colorectal cancer patients and 500 cancer- free controls were genotyped for the p53 Arg72Pro polymorphism by an allele-specific PCR, and by a PCR-RFLP for the XRCC1 polymorphism. Genotype frequencies were compared between cases and controls. Results: The number of p53 codon 72 Pro homozygotes and heterozygotes was higher among colorectal cancer patients than in the control group (53 vs. 28 and 188 vs. 123, respectively). Having the Pro homozygous genotype (OR: 2.00, 95% CI: 1.25-3.21) or carrying the Pro allele (OR: 2.15, 95% CI: 1.66-2.79) was associated with an elevated risk for colorectal cancer. The occurrence of XRCC1 heterozygotes (236 vs. 216) and Gln homozygotes (78 vs. 65) was higher among cases than in controls. Glncarriers occurred more frequently among patients than in cancer-free controls (OR: 1.32, 95%CI: 1.02-1.69). Combined analysis of 7 polymorphisms showed that carrying at least 6 highrisk alleles substantially increases the risk of colorectal cancer (OR: 6.39, 95%CI: 2.73-14.92). Conclusions: The p53 Arg72Pro and XRCC1 Arg399Gln polymorphisms affect the risk of colorectal cancer. Accuracy of risk estimation can be increased by a simultaneous analysis of several allelic polymorphisms.
|Translated title of the contribution||Interaction between allelic polymorphisms in the modification of the risk of colorectal cancer in the Hungarian population|
|Number of pages||8|
|Journal||European Journal of Oncology|
|Publication status||Published - Dec 1 2011|
- Colorectal cancer
- X-ray cross complementing 1
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