Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici

Translated title of the contribution: Interaction between allelic polymorphisms in the modification of the risk of colorectal cancer in the Hungarian population

István Kiss, Zsuzsa Orsós, Katalin Gombos, Barna Bogner, Antal Tibold, András Csejtei, István Szanyi, Zsuzsanna Varga, Gábor Rébék-Nagy, I. Ember

Research output: Contribution to journalArticle

Abstract

Aim: The effect of p53 Arg72Pro, and X-ray cross complementing 1 Arg399Gln allelic polymorphisms on the risk of colorectal cancer was studied in a case control study. The results were combined with the data from a previous study (polymorphisms of metabolizing enzymes), and a combined analysis for the joint effect of 7 allelic polymorphisms was also performed. Materials and methods: Five hundred colorectal cancer patients and 500 cancer- free controls were genotyped for the p53 Arg72Pro polymorphism by an allele-specific PCR, and by a PCR-RFLP for the XRCC1 polymorphism. Genotype frequencies were compared between cases and controls. Results: The number of p53 codon 72 Pro homozygotes and heterozygotes was higher among colorectal cancer patients than in the control group (53 vs. 28 and 188 vs. 123, respectively). Having the Pro homozygous genotype (OR: 2.00, 95% CI: 1.25-3.21) or carrying the Pro allele (OR: 2.15, 95% CI: 1.66-2.79) was associated with an elevated risk for colorectal cancer. The occurrence of XRCC1 heterozygotes (236 vs. 216) and Gln homozygotes (78 vs. 65) was higher among cases than in controls. Glncarriers occurred more frequently among patients than in cancer-free controls (OR: 1.32, 95%CI: 1.02-1.69). Combined analysis of 7 polymorphisms showed that carrying at least 6 highrisk alleles substantially increases the risk of colorectal cancer (OR: 6.39, 95%CI: 2.73-14.92). Conclusions: The p53 Arg72Pro and XRCC1 Arg399Gln polymorphisms affect the risk of colorectal cancer. Accuracy of risk estimation can be increased by a simultaneous analysis of several allelic polymorphisms.

Original languageItalian
Pages (from-to)203-210
Number of pages8
JournalEuropean Journal of Oncology
Volume16
Issue number4
Publication statusPublished - Dec 2011

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Colorectal Neoplasms
Population
Alleles
Homozygote
Heterozygote
Genotype
Polymerase Chain Reaction
Codon
Restriction Fragment Length Polymorphisms
Case-Control Studies
Neoplasms
X-Rays
Control Groups
Enzymes

Keywords

  • Colorectal cancer
  • P53
  • Polymorphism
  • X-ray cross complementing 1

ASJC Scopus subject areas

  • Oncology

Cite this

Kiss, I., Orsós, Z., Gombos, K., Bogner, B., Tibold, A., Csejtei, A., ... Ember, I. (2011). Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici. European Journal of Oncology, 16(4), 203-210.

Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici. / Kiss, István; Orsós, Zsuzsa; Gombos, Katalin; Bogner, Barna; Tibold, Antal; Csejtei, András; Szanyi, István; Varga, Zsuzsanna; Rébék-Nagy, Gábor; Ember, I.

In: European Journal of Oncology, Vol. 16, No. 4, 12.2011, p. 203-210.

Research output: Contribution to journalArticle

Kiss, I, Orsós, Z, Gombos, K, Bogner, B, Tibold, A, Csejtei, A, Szanyi, I, Varga, Z, Rébék-Nagy, G & Ember, I 2011, 'Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici', European Journal of Oncology, vol. 16, no. 4, pp. 203-210.
Kiss I, Orsós Z, Gombos K, Bogner B, Tibold A, Csejtei A et al. Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici. European Journal of Oncology. 2011 Dec;16(4):203-210.
Kiss, István ; Orsós, Zsuzsa ; Gombos, Katalin ; Bogner, Barna ; Tibold, Antal ; Csejtei, András ; Szanyi, István ; Varga, Zsuzsanna ; Rébék-Nagy, Gábor ; Ember, I. / Rischio di tumore colon-rettale nella popolazione ungherese in relazione ai polimorfismi allelici. In: European Journal of Oncology. 2011 ; Vol. 16, No. 4. pp. 203-210.
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abstract = "Aim: The effect of p53 Arg72Pro, and X-ray cross complementing 1 Arg399Gln allelic polymorphisms on the risk of colorectal cancer was studied in a case control study. The results were combined with the data from a previous study (polymorphisms of metabolizing enzymes), and a combined analysis for the joint effect of 7 allelic polymorphisms was also performed. Materials and methods: Five hundred colorectal cancer patients and 500 cancer- free controls were genotyped for the p53 Arg72Pro polymorphism by an allele-specific PCR, and by a PCR-RFLP for the XRCC1 polymorphism. Genotype frequencies were compared between cases and controls. Results: The number of p53 codon 72 Pro homozygotes and heterozygotes was higher among colorectal cancer patients than in the control group (53 vs. 28 and 188 vs. 123, respectively). Having the Pro homozygous genotype (OR: 2.00, 95{\%} CI: 1.25-3.21) or carrying the Pro allele (OR: 2.15, 95{\%} CI: 1.66-2.79) was associated with an elevated risk for colorectal cancer. The occurrence of XRCC1 heterozygotes (236 vs. 216) and Gln homozygotes (78 vs. 65) was higher among cases than in controls. Glncarriers occurred more frequently among patients than in cancer-free controls (OR: 1.32, 95{\%}CI: 1.02-1.69). Combined analysis of 7 polymorphisms showed that carrying at least 6 highrisk alleles substantially increases the risk of colorectal cancer (OR: 6.39, 95{\%}CI: 2.73-14.92). Conclusions: The p53 Arg72Pro and XRCC1 Arg399Gln polymorphisms affect the risk of colorectal cancer. Accuracy of risk estimation can be increased by a simultaneous analysis of several allelic polymorphisms.",
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AU - Kiss, István

AU - Orsós, Zsuzsa

AU - Gombos, Katalin

AU - Bogner, Barna

AU - Tibold, Antal

AU - Csejtei, András

AU - Szanyi, István

AU - Varga, Zsuzsanna

AU - Rébék-Nagy, Gábor

AU - Ember, I.

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N2 - Aim: The effect of p53 Arg72Pro, and X-ray cross complementing 1 Arg399Gln allelic polymorphisms on the risk of colorectal cancer was studied in a case control study. The results were combined with the data from a previous study (polymorphisms of metabolizing enzymes), and a combined analysis for the joint effect of 7 allelic polymorphisms was also performed. Materials and methods: Five hundred colorectal cancer patients and 500 cancer- free controls were genotyped for the p53 Arg72Pro polymorphism by an allele-specific PCR, and by a PCR-RFLP for the XRCC1 polymorphism. Genotype frequencies were compared between cases and controls. Results: The number of p53 codon 72 Pro homozygotes and heterozygotes was higher among colorectal cancer patients than in the control group (53 vs. 28 and 188 vs. 123, respectively). Having the Pro homozygous genotype (OR: 2.00, 95% CI: 1.25-3.21) or carrying the Pro allele (OR: 2.15, 95% CI: 1.66-2.79) was associated with an elevated risk for colorectal cancer. The occurrence of XRCC1 heterozygotes (236 vs. 216) and Gln homozygotes (78 vs. 65) was higher among cases than in controls. Glncarriers occurred more frequently among patients than in cancer-free controls (OR: 1.32, 95%CI: 1.02-1.69). Combined analysis of 7 polymorphisms showed that carrying at least 6 highrisk alleles substantially increases the risk of colorectal cancer (OR: 6.39, 95%CI: 2.73-14.92). Conclusions: The p53 Arg72Pro and XRCC1 Arg399Gln polymorphisms affect the risk of colorectal cancer. Accuracy of risk estimation can be increased by a simultaneous analysis of several allelic polymorphisms.

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