Interacting biological and electronic neurons generate realistic oscillatory rhythms

Attila Szücs, Pablo Varona, Alexander R. Volkovskii, Henry D.I. Abarbanel, Mikhail I. Rabinovich, Allen I. Selverston

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Small assemblies of neurons such as central pattern generators (CPG) are known to express regular oscillatory firing patterns comprising bursts of action potentials. In contrast, individual CPG neurons isolated from the remainder of the network can generate irregular firing patterns. In our study of cooperative behavior in CPGs we developed an analog electronic neuron (EN) that reproduces firing patterns observed in lobster pyloric CPG neurons. Using a tuneable artificial synapse we connected the EN bidirectionally to neurons of this CPG. We found that the periodic bursting oscillation of this mixed assembly depends on the strength and sign of the electrical coupling. Working with identified, isolated pyloric CPG neurons whose network rhythms were impaired, the EN/biological network restored the characteristic CPG rhythm both when the EN oscillations are regular and when they are irregular. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)563-569
Number of pages7
JournalNeuroreport
Volume11
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Electronic neuron
  • Electronic synapse
  • Oscillatory rhythm
  • Pyloric neurons
  • Regularization
  • Synchronization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Szücs, A., Varona, P., Volkovskii, A. R., Abarbanel, H. D. I., Rabinovich, M. I., & Selverston, A. I. (2000). Interacting biological and electronic neurons generate realistic oscillatory rhythms. Neuroreport, 11(3), 563-569. https://doi.org/10.1097/00001756-200002280-00027