Inter-monomer cross-linking affects the thermal transitions in F-actin

F. Könczöl, D. Lorinczy, Zs Vértes, G. Hegyi, J. Belagyi

Research output: Contribution to journalArticle

7 Citations (Scopus)


Chemical cross-links which covalently connected the Cys-374 and Glu-41 residues of adjacent monomers in the same strand of F-actin were used to follow the consequences of the modification for the motional and structural properties of the actin filaments. DSC measurements reported that the inter-monomer cross-links shifted the thermal transition temperature and affected strongly the cooperativity of the transition in comparison with uncross-linked F-actin. Addition of HMM to F-actin induced significant decrease of the transition temperature to lower value from 69.4 to 67. 5 °C.

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Issue number2
Publication statusPublished - Aug 1 2010


  • Actin cross-linking
  • DSC
  • Thermal stability

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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