Intelligent drug delivery systems obtained by radiation

Flavia Martellini, Olga Z. Higa, E. Takács, Agneza Safranj, Masaru Yoshida, Ryoichi Katakai, Mario Carenza

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Radiation-induced polymerization of acryloyl-L-proline methyl ester, an α-aminoacid-containing monomer, in the presence of a crosslinking agent and a hydrophilic monomer gave rise to polymer hydrogels whose water content at equilibrium was found to decrease as the swelling temperature increased. Some hydrogel samples were obtained with entrapped acetaminophen, an analgesic and antipyretic drug. It was ascertained that the release of the drug was controlled by both/the hydrophilicity of the polymer matrices and the environmental temperature.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalRadiation Physics and Chemistry
Volume52
Issue number1-6
DOIs
Publication statusPublished - Jun 1998

Fingerprint

delivery
drugs
monomers
polymers
radiation
crosslinking
swelling
moisture content
ambient temperature
esters
polymerization
matrices
temperature

Keywords

  • Acetaminophen
  • Controlled release
  • Poly(acryloyl-L- proline methyl ester)
  • Radiation polymerization
  • Thermosensitive hydrogel

ASJC Scopus subject areas

  • Radiation

Cite this

Martellini, F., Higa, O. Z., Takács, E., Safranj, A., Yoshida, M., Katakai, R., & Carenza, M. (1998). Intelligent drug delivery systems obtained by radiation. Radiation Physics and Chemistry, 52(1-6), 295-299. https://doi.org/10.1016/S0969-806X(98)00156-X

Intelligent drug delivery systems obtained by radiation. / Martellini, Flavia; Higa, Olga Z.; Takács, E.; Safranj, Agneza; Yoshida, Masaru; Katakai, Ryoichi; Carenza, Mario.

In: Radiation Physics and Chemistry, Vol. 52, No. 1-6, 06.1998, p. 295-299.

Research output: Contribution to journalArticle

Martellini, F, Higa, OZ, Takács, E, Safranj, A, Yoshida, M, Katakai, R & Carenza, M 1998, 'Intelligent drug delivery systems obtained by radiation', Radiation Physics and Chemistry, vol. 52, no. 1-6, pp. 295-299. https://doi.org/10.1016/S0969-806X(98)00156-X
Martellini, Flavia ; Higa, Olga Z. ; Takács, E. ; Safranj, Agneza ; Yoshida, Masaru ; Katakai, Ryoichi ; Carenza, Mario. / Intelligent drug delivery systems obtained by radiation. In: Radiation Physics and Chemistry. 1998 ; Vol. 52, No. 1-6. pp. 295-299.
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