Intelligent drug delivery systems obtained by radiation

Flavia Martellini, Olga Z. Higa, Erzsebet Takacs, Agneza Safranj, Masaru Yoshida, Ryoichi Katakai, Mario Carenza

Research output: Contribution to journalArticle

10 Citations (Scopus)


Radiation-induced polymerization of acryloyl-L-proline methyl ester, an α-aminoacid-containing monomer, in the presence of a crosslinking agent and a hydrophilic monomer gave rise to polymer hydrogels whose water content at equilibrium was found to decrease as the swelling temperature increased. Some hydrogel samples were obtained with entrapped acetaminophen, an analgesic and antipyretic drug. It was ascertained that the release of the drug was controlled by both/the hydrophilicity of the polymer matrices and the environmental temperature.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalRadiation Physics and Chemistry
Issue number1-6
Publication statusPublished - Jun 1 1998



  • Acetaminophen
  • Controlled release
  • Poly(acryloyl-L- proline methyl ester)
  • Radiation polymerization
  • Thermosensitive hydrogel

ASJC Scopus subject areas

  • Radiation

Cite this

Martellini, F., Higa, O. Z., Takacs, E., Safranj, A., Yoshida, M., Katakai, R., & Carenza, M. (1998). Intelligent drug delivery systems obtained by radiation. Radiation Physics and Chemistry, 52(1-6), 295-299.