Radiation-induced polymerization of acryloyl-L-proline methyl ester, an α-aminoacid-containing monomer, in the presence of a crosslinking agent and a hydrophilic monomer gave rise to polymer hydrogels whose water content at equilibrium was found to decrease as the swelling temperature increased. Some hydrogel samples were obtained with entrapped acetaminophen, an analgesic and antipyretic drug. It was ascertained that the release of the drug was controlled by both/the hydrophilicity of the polymer matrices and the environmental temperature.
- Controlled release
- Poly(acryloyl-L- proline methyl ester)
- Radiation polymerization
- Thermosensitive hydrogel
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