Integration of signals mediated by B-cell receptor, B-cell activating factor of the tumor necrosis factor family (BAFF) and Fas (CD95)

Anikó Hancz, Zoltán Hérincs, Zsuzsa Neer, G. Sármay, G. Koncz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The survival of the mature resting B cells depends on signaling from B cell receptor (BCR), and a plethora of positive and negative regulators, that maintain cellular homeostasis and ultimately determine cell's fate, i.e., survival or programmed death (apoptosis). Among these regulators we have investigated the B cell activating factor belonging to tumor necrosis factor family (BAFF) and the prototypic death receptor Fas/CD95 mediated signals. We have shown that BAFF inhibits Fas-mediated cell death, however, the BCR-driven survival signals were not strengthened by BAFF. Therefore, we propose that BAFF may function independently of the antigen specificity of BCR, thus may enhance the risk of autoimmune diseases by promoting the survival of bystander B cells in the germinal center.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalImmunology Letters
Volume116
Issue number2
DOIs
Publication statusPublished - Mar 15 2008

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Interleukin-4 Receptors
B-Lymphocytes
Tumor Necrosis Factor-alpha
B-Cell Activating Factor
Death Domain Receptors
B-Cell Antigen Receptors
Germinal Center
Autoimmune Diseases
Homeostasis
Cell Death
Apoptosis

Keywords

  • Apoptosis
  • B-cell
  • BAFF
  • Fas
  • Selection
  • Signaling

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Integration of signals mediated by B-cell receptor, B-cell activating factor of the tumor necrosis factor family (BAFF) and Fas (CD95). / Hancz, Anikó; Hérincs, Zoltán; Neer, Zsuzsa; Sármay, G.; Koncz, G.

In: Immunology Letters, Vol. 116, No. 2, 15.03.2008, p. 211-217.

Research output: Contribution to journalArticle

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AU - Koncz, G.

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