A prefrontális kéreg piramissejtjeinek integráló szerepe a neuronális és glia eredetu{double acute} információk feldolgozásában, patkányban; a kognitív funkciók és az addiktív viselkedés purinerg mechanizmusokkal történo{double acute} szabályozása

Translated title of the contribution: Integration of neuronal and glial signalling by pyramidal cells of the rat prefrontal cortex; control of cognitive functions and addictive behaviour by purinergic mechanisms

Ute Krügel, László Köles, Peter Illes

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The medial prefrontal cortex (PFC) is thought to be the highest order association area in the mammalian cortex which is involved in cognitive functions. Especially, layer V pyramidal cells integrating aferent innervations from dopaminergic cell groups in the ventral tegmental area, glutamatergic inputs from the thalamus and neighbouring PFC pyramical cells, as well as GABAergic inputs from local interneurons are crucial for processing short-term working memory. These neurons are endowed with the NMDA- and AMPA-type excitatory amino acid receptors, described to be involved in the regulation of synaptic plasticity, the apparent basis of elementary learning processes. NMDA receptor currents were in fact regulated on the one hand by dopamine D1 receptors and on the other hand by ATP-sensitive receptors of the P2Y-type. P2Y4 receptors acted indirectly to potentiate NMDA receptor-currents by releasing vesicular glutamate from astrocytes, or attenuated these currents directly by stimulating P2Y1 receptors located at the PFC cells themselves. Long-term depression (LTD) induced in PFC pyramidal neurons could be blocked by P2Y1 receptors in a manner not depending on NMDA receptors but targeting voltage-sensitive dendritic Ca2+ channels. In vivo data also support the notion that P2Y1 receptors participate in the regulation of cognitive processes and addiction. For example, in a spatial delayed win-shift task, P2Y1 receptor-activation has been shown to deteriorate not the primary storage of information but its processing during and after a delay. Further, it is widely accepted that behavioural sensitization in animals provides a model for the intensifcation of drug craving believed to underlie addiction in humans. In fact, sensitization to amphetamine was interrupted by the blockade of P2Y1 receptors in the mesocortico-limbic dopaminergic system.

Original languageHungarian
Pages (from-to)206-213
Number of pages8
JournalNeuropsychopharmacologia Hungarica
Volume15
Issue number4
Publication statusPublished - Dec 1 2013

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

Cite this