Insulin treatment and weight gain in type 2 diabetes

Is our knowledge complete?

Miriam Ryan, B. Livingstone, Patrick Ritz

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The majority of type 2 diabetic patients are overweight and any excess weight, or weight gain, adversely affects glycaemic control. Paradoxically, antidiabetic agents used to improve glycaemic control are frequently associated with weight gain, particularly insulin therapy. Such weight gain further deteriorates glycaemic control and increases insulin resistance. Understanding body weight regulation in type 2 diabetic patients is therefore necessary to better adapt for the effect of such medication on weight. Expressed in terms of energy, weight gain results from positive energy balance. Positive energy balance in type 2 diabetes is most usually attributed to decreased energy expenditure and the cessation of glycosuric energy loss following the initiation of hypoglycaemic treatment. It appears from current literature however that these two factors, even in combination, cannot completely explain observed weight gain. Indeed, the precise contribution of energy intake and appetite, a key determinant of energy intake, to this positive energy balance remains a black box. In this review the potential contribution of a change in feeding regimen to weight gain associated with insulin treatment is assessed, with particular attention being paid to insulin's effect within the brain.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalCurrent Nutrition and Food Science
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2006

Fingerprint

noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Weight Gain
insulin
weight gain
Insulin
glycemic control
energy balance
Energy Intake
Hypoglycemic Agents
energy intake
Therapeutics
hypoglycemic agents
Weights and Measures
energy
Appetite
appetite
insulin resistance
energy expenditure
Energy Metabolism

Keywords

  • Diabetes
  • Energy intake
  • Insulin
  • Weight gain

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health
  • Food Science

Cite this

Insulin treatment and weight gain in type 2 diabetes : Is our knowledge complete? / Ryan, Miriam; Livingstone, B.; Ritz, Patrick.

In: Current Nutrition and Food Science, Vol. 2, No. 1, 02.2006, p. 51-58.

Research output: Contribution to journalReview article

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