Insulin resistance and oral cancer risk

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Insulin resistance is an increasingly prevalent disorder in the developed countries and is known as high risk factor for both cardiovascular diseases and malignancies. All phases of insulin resistance, such as hyperinsulinemia, hyperglycemia, metabolic syndrome and type-2 diabetes are proven risk factors for cancers at many sites. These associations are to be systematically explored for further cancer types. Oral cancer is regarded as a typical example of smoking associated tumors and till now the exogenous harmful noxae were overemphasized in its epidemiology. Recently, after some years of decline both incidence and mortality of oral cavity cancer have been rising again in spite of the decreased ratio of smokers in many developed countries. The decreasing male to female ratio and the continuously increasing prevalence of nonsmoker non-drinker patients among oral cancer cases focused the attention to search for further possible risk factors. Earlier results of our working group revealed a significant association between type- 2 diabetes and oral cancer risk on pooled population of patients. Moreover, separated investigations on male and female cases justified that insulin resistance is a higher risk for oral cancer among women as compared with men. The present case-control study aimed to clarify the risk factors for smoking associated oral cancer among non-smoker, non-drinker women. Elevated fasting glucose level and obesity proved to be signifinantly higher risk factors for oral cancer among nonsmoker, non-drinker female patients as compared with smoker cases. These results suggest that high prevalence of insulin resistance among women can cause increased oral cancer risk even without smoking. Correlations between insulin resistance and tumor risk reveal new possibilities in the prevention and treatment of oral cancer. Healthy diet, physical activity and weight loss increase the insulin sensitivity, and decrease the risk for oral cancer.

Original languageEnglish
Title of host publicationHorizons in Cancer Research. Volume 43
PublisherNova Science Publishers, Inc.
Pages77-97
Number of pages21
ISBN (Electronic)9781611224085
ISBN (Print)9781611220476
Publication statusPublished - Jan 1 2011

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Keywords

  • Elevated fasting glucose
  • Insulin resistance
  • Metabolic syndrome
  • Obesity
  • Oral cancer risk
  • Type-2 diabetes

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Suba, Z. (2011). Insulin resistance and oral cancer risk. In Horizons in Cancer Research. Volume 43 (pp. 77-97). Nova Science Publishers, Inc..