The new oxidovanadium complexes [VIVO(pic-trpMe)2] (1) and [VVO(pic-trpH)tpa]2+ (2), where pic-trpMe = bis(pyridine-5-L-tryptophanmethylester-2-carboxylate and tpa = tris(methyl pyridyl)amine, have been synthesised and characterised. The speciation in the systems VO2+/picH-trpH has been revealed for the pH range 3-8, showing that the dominating complexes in aqueoussolution are [VO(pic-trpH)(pic-trp)]- (pH 3-5.5) and [VO(pic-trp)(OH)]- (pH 5-7). The inhibition of lipolysis, one of the functions of insulin, has been studied in vitro, using rat adipocytes. Complex 2 and [VO(tpa)SO4] 3, and also picH-tprMe show some activity (2 > [VO(tpa)SO4] > picH-tprMe), although not to the extent of [VOSO4] (IC50 = 0.81(20), 2: 1.84(40)).
|Number of pages||7|
|Journal||Journal of the Argentine Chemical Society|
|Publication status||Published - Jan 1 2009|
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