Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine

Hoss Esbak, Jessica Nilsson, Ebbe Nordlander, Eva A. Enyedy, Tamás Kissc, Yutaka Yoshikawad, Hiromu Sakurai, Dieter Rehder

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Abstract

The new oxidovanadium complexes [VIVO(pic-trpMe)2] (1) and [VVO(pic-trpH)tpa]2+ (2), where pic-trpMe = bis(pyridine-5-L-tryptophanmethylester-2-carboxylate and tpa = tris(methyl pyridyl)amine, have been synthesised and characterised. The speciation in the systems VO2+/picH-trpH has been revealed for the pH range 3-8, showing that the dominating complexes in aqueoussolution are [VO(pic-trpH)(pic-trp)]- (pH 3-5.5) and [VO(pic-trp)(OH)]- (pH 5-7). The inhibition of lipolysis, one of the functions of insulin, has been studied in vitro, using rat adipocytes. Complex 2 and [VO(tpa)SO4] 3, and also picH-tprMe show some activity (2 > [VO(tpa)SO4] > picH-tprMe), although not to the extent of [VOSO4] (IC50 = 0.81(20), 2: 1.84(40)).

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalJournal of the Argentine Chemical Society
Volume97
Issue number1
Publication statusPublished - Jan 1 2009

Keywords

  • Insulin-mimetic
  • Oxidovanadium
  • Picolinate
  • Speciation
  • Vanadium

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Esbak, H., Nilsson, J., Nordlander, E., Enyedy, E. A., Kissc, T., Yoshikawad, Y., Sakurai, H., & Rehder, D. (2009). Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine. Journal of the Argentine Chemical Society, 97(1), 51-57.