Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine

Hoss Esbak, Jessica Nilsson, Ebbe Nordlander, E. Enyedy, Tamás Kissc, Yutaka Yoshikawad, Hiromu Sakurai, Dieter Rehder

Research output: Contribution to journalArticle

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Abstract

The new oxidovanadium complexes [VIVO(pic-trpMe)2] (1) and [VVO(pic-trpH)tpa]2+ (2), where pic-trpMe = bis(pyridine-5-L-tryptophanmethylester-2-carboxylate and tpa = tris(methyl pyridyl)amine, have been synthesised and characterised. The speciation in the systems VO2+/picH-trpH has been revealed for the pH range 3-8, showing that the dominating complexes in aqueoussolution are [VO(pic-trpH)(pic-trp)]- (pH 3-5.5) and [VO(pic-trp)(OH)]- (pH 5-7). The inhibition of lipolysis, one of the functions of insulin, has been studied in vitro, using rat adipocytes. Complex 2 and [VO(tpa)SO4] 3, and also picH-tprMe show some activity (2 > [VO(tpa)SO4] > picH-tprMe), although not to the extent of [VOSO4] (IC50 = 0.81(20), 2: 1.84(40)).

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalJournal of the Argentine Chemical Society
Volume97
Issue number1
Publication statusPublished - Jan 2009

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Amines
Rats
Insulin
pyridine
Lipolysis
vanadyl sulfate

Keywords

  • Insulin-mimetic
  • Oxidovanadium
  • Picolinate
  • Speciation
  • Vanadium

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine. / Esbak, Hoss; Nilsson, Jessica; Nordlander, Ebbe; Enyedy, E.; Kissc, Tamás; Yoshikawad, Yutaka; Sakurai, Hiromu; Rehder, Dieter.

In: Journal of the Argentine Chemical Society, Vol. 97, No. 1, 01.2009, p. 51-57.

Research output: Contribution to journalArticle

Esbak, H, Nilsson, J, Nordlander, E, Enyedy, E, Kissc, T, Yoshikawad, Y, Sakurai, H & Rehder, D 2009, 'Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine', Journal of the Argentine Chemical Society, vol. 97, no. 1, pp. 51-57.
Esbak, Hoss ; Nilsson, Jessica ; Nordlander, Ebbe ; Enyedy, E. ; Kissc, Tamás ; Yoshikawad, Yutaka ; Sakurai, Hiromu ; Rehder, Dieter. / Insulin-mimetic and speciation studies of oxidovanadium complexes containing picolyltryptophane and tris(pyridyl)amine. In: Journal of the Argentine Chemical Society. 2009 ; Vol. 97, No. 1. pp. 51-57.
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