Insights into the structure and function of the hippocampal formation: Relevance to Parkinson's disease

Orsolya Györfi, Helga Nagy, Magdolna Bokor, S. Kéri

Research output: Contribution to journalReview article

1 Citation (Scopus)


The link between the hippocampus and declarative memory dysfunctions following the removal of the medial temporal lobe opened unexplored fields in neuroscience. In the first part of our review, we summarized current theoretical frameworks discussing the role of hippocampus in learning and memory. Several theories are highlighted suggesting that the hippocampus is responsible for assembling stimulus elements into a unitary representation that later can be utilized to simulate future events. The hippocampal formation has been implicated in a growing number of disorders, from neurodegenerative diseases to atypical cognitive ageing and depression. Recent neuroimaging studies provided new opportunities to study in detail the hippocampal formation's role in higher levels of the nervous system. We will present data regarding the regional specialization of the hippocampus in experimental models developed for healthy and neurological conditions with a special focus on Parkinson's disease. Combined evidence from neuroimaging studies suggested that hippocampal volume is reduced in non-demented, newly diagnosed patients with Parkinson's disease, which is associated with impaired memory performance. These findings proposed that, beyond the wellknown striatal dopamine loss, impaired hippocampal synaptic plasticity may contribute to cognitive and affective impairments in early Parkinson's disease.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalIdeggyogyaszati Szemle
Issue number1-2
Publication statusPublished - Jan 30 2018


  • Hippocampal formation
  • Learning
  • Memory
  • Neuroimaging
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Insights into the structure and function of the hippocampal formation: Relevance to Parkinson's disease'. Together they form a unique fingerprint.

  • Cite this