Insights into the regulation of the ryanodine receptor: Differential effects of Mg2+ and Ca2+ on ATP binding

José M. Dias, Csaba Szegedi, Istvan Jóna, Pia D. Vogel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Calcium ions are frequently used second messengers in most living organisms. Members of the family of ryanodine sensitive calcium channels (ryanodine receptors, RyRs) are responsible for many important Ca2+ signaling events in both excitable and nonexcitable cells. The biological activity of these membrane proteins is modulated and regulated by a great variety of different cellular and extracellular effectors, proteins, and small molecules. However, very little is still understood about how the modulators work on a molecular level. The very large size of more than 2 million Da per functional tetrameric RyR unit and its membrane association have made more detailed biochemical and structural analysis extremely challenging.

Original languageEnglish
Pages (from-to)9408-9415
Number of pages8
JournalBiochemistry
Volume45
Issue number31
DOIs
Publication statusPublished - Aug 8 2006

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ASJC Scopus subject areas

  • Biochemistry

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