Az ACE gén polimorfizmusának befolyása a szénhidrát-anyagcserére, az oxidatív stresszre és a célszervkárosodásra 2-es típusú diabetesben

Translated title of the contribution: Insertion/deletion polymorphism of the angiotensin converting enzyme gene influences carbohydrate metabolism, oxidative stress and target organ damage in type 2 diabetes mellitus

Gergo Attila Molnár, Zoltán Wagner, L. Wágner, B. Melegh, T. Kőszegi, Péter Degrell, J. Bene, Mónika Tamaskó, Boglárka Laczy, J. Nagy, I. Wittmann

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

ACE gene insertion/deletion (I/D) polymorphism is a well-known risk factor of hypertension, cardiovascular diseases and progression of diabetic nephropathy. In carriers of allele D, serum level of angiotensin-II is higher, which can be associated with increased oxidative stress and subsequent endothelial damage. Albuminuria is a sensitive marker of endothelial damage, while serum activity of the enzyme γ-glutamyl transferase - that plays important role in the antioxidant defense - may refer to the level of oxidative stress. The present paper reports on a cross-sectional clinical study, where authors have examined on the relation between ACE gene insertion/deletion polymorphism and carbohydrate metabolism, hypertension as well as albuminuria in type 2 diabetics (n = 145). In patients carrying allele D, fructosamine levels were significantly higher (p = 0.007) than in carriers of allele I. Patients with II + ID genotypes and those who were treated with insulin took more antihypertensive drugs than the ones with II genotype or orally treated (p = 0.015). They found a significant association between genotype and fructosamine level (p = 0.023). Association between genotype or modality of treatment of diabetes (oral vs, insulin) and combined treatment of hypertension (number of antihypertensive drugs) was of borderline significance. They found that fructosamin level of patients receiving ACE inhibitor was lower than that of patients not receiving ACE inhibitors. In patients with allele D, they have also found higher activity of γ-GT and higher albuminuria. From this results and data of the literature the authors conclude that because of insulin resistance (in connection with the presence of allele D), these patients tend to have a worse metabolic state, more advanced glycation products, due to which oxidative stress and endothelial cell damage may develop. As albuminuria and activity of γ-GT were both found higher in patients with allele D, and our patients did not suffer of any hepatic disease, authors take the consequence that γ-GT is a marker of the oxidative stress caused by allele D. Endothelial damage may explain that these patients take a higher number of antihypertensive combination. Based on this, D allele may contribute - via increased glycation and oxidative stress - to the target organ damage in type 2 diabetes.

Original languageHungarian
Pages (from-to)855-859
Number of pages5
JournalOrvosi Hetilap
Volume145
Issue number16
Publication statusPublished - Apr 2004

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Carbohydrate Metabolism
Peptidyl-Dipeptidase A
Type 2 Diabetes Mellitus
Oxidative Stress
Alleles
Albuminuria
Genes
Genotype
Antihypertensive Agents
Fructosamine
Insertional Mutagenesis
Gene Deletion
Hypertension
Angiotensin-Converting Enzyme Inhibitors
Insulin
Diabetic Nephropathies
Transferases
Serum
Angiotensin II
Disease Progression

ASJC Scopus subject areas

  • Medicine(all)

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Az ACE gén polimorfizmusának befolyása a szénhidrát-anyagcserére, az oxidatív stresszre és a célszervkárosodásra 2-es típusú diabetesben. / Molnár, Gergo Attila; Wagner, Zoltán; Wágner, L.; Melegh, B.; Kőszegi, T.; Degrell, Péter; Bene, J.; Tamaskó, Mónika; Laczy, Boglárka; Nagy, J.; Wittmann, I.

In: Orvosi Hetilap, Vol. 145, No. 16, 04.2004, p. 855-859.

Research output: Contribution to journalArticle

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AU - Wagner, Zoltán

AU - Wágner, L.

AU - Melegh, B.

AU - Kőszegi, T.

AU - Degrell, Péter

AU - Bene, J.

AU - Tamaskó, Mónika

AU - Laczy, Boglárka

AU - Nagy, J.

AU - Wittmann, I.

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